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Trace amine associated receptor 6
Identifiers
Symbols TAAR6; RP11-295F4.3; SCZD5; TA4; TRAR4
External IDs OMIM608923 MGI2685074 HomoloGene27874 IUPHAR: TAAR6 GeneCards: TAAR6 Gene
RNA expression pattern
PBB GE TAAR6 gnf1h10296 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 319100 215855
Ensembl ENSG00000146383 ENSMUSG00000045111
UniProt Q96RI8 Q5QD13
RefSeq (mRNA) NM_175067 NM_001010828
RefSeq (protein) NP_778237 NP_001010828
Location (UCSC) Chr 6:
132.93 - 132.93 Mb
Chr 10:
23.67 - 23.68 Mb
PubMed search [1] [2]

Trace amine associated receptor 6, also known as TAAR6, is a protein which in humans is encoded by the TAAR6 gene.[1][2]

Function

TAAR6 belongs to the trace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.[3][4]

References

  1. ^ Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966–71. doi:10.1073/pnas.151105198. PMID 11459929.  
  2. ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.  
  3. ^ Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV (October 2004). "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia". Am. J. Hum. Genet. 75 (4): 624–38. doi:10.1086/424887. PMID 15329799.  
  4. ^ "Entrez Gene: TAAR6 trace amine associated receptor 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=319100.  

Further reading

  • Cao Q, Martinez M, Zhang J, et al. (1997). "Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees.". Genomics 43 (1): 1–8. doi:10.1006/geno.1997.4815. PMID 9226366.  
  • Kaufmann CA, Suarez B, Malaspina D, et al. (1998). "NIMH Genetics Initiative Millennium Schizophrenia Consortium: linkage analysis of African-American pedigrees.". Am. J. Med. Genet. 81 (4): 282–9. doi:10.1002/(SICI)1096-8628(19980710)81:4<282::AID-AJMG2>3.0.CO;2-W. PMID 9674972.  
  • Borowsky B, Adham N, Jones KA, et al. (2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors.". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966–71. doi:10.1073/pnas.151105198. PMID 11459929.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Duan J, Martinez M, Sanders AR, et al. (2004). "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia.". Am. J. Hum. Genet. 75 (4): 624–38. doi:10.1086/424887. PMID 15329799.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Lindemann L, Ebeling M, Kratochwil NA, et al. (2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.". Genomics 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.  
  • Amann D, Avidan N, Kanyas K, et al. (2006). "The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23.". Mol. Psychiatry 11 (2): 119–21. doi:10.1038/sj.mp.4001752. PMID 16189505.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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