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T-cell acute lymphocytic leukemia 1
Identifiers
Symbols TAL1; SCL; TCL5; tal-1
External IDs OMIM187040 MGI98480 HomoloGene2400 GeneCards: TAL1 Gene
RNA expression pattern
PBB GE TAL1 206283 s at tn.png
PBB GE TAL1 216925 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6886 21349
Ensembl ENSG00000162367 ENSMUSG00000028717
UniProt P17542 Q3TZH7
RefSeq (mRNA) NM_003189 NM_011527
RefSeq (protein) NP_003180 NP_035657
Location (UCSC) Chr 1:
47.45 - 47.47 Mb
Chr 4:
114.55 - 114.57 Mb
PubMed search [1] [2]

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.[1][2]

The protein encoded by TAL1 is a basic-helix-loop-helix transcription factor.

Contents

Interactions

TAL1 has been shown to interact with LMO1,[3][4] LDB1,[5] SIN3A,[6] LMO2,[4][3][5][7] Sp1 transcription factor,[8] TCF3,[5][9] CBFA2T3,[5] EP300[10] and GATA1.[5][7]

References

  1. ^ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (Aug 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A 86 (13): 5039–43. PMID 2740341.  
  2. ^ "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6886.  
  3. ^ a b Valge-Archer, V E; Osada H, Warren A J, Forster A, Li J, Baer R, Rabbitts T H (Aug. 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (18): 8617–21. ISSN 0027-8424. PMID 8078932.  
  4. ^ a b Wadman, I; Li J, Bash R O, Forster A, Osada H, Rabbitts T H, Baer R (Oct. 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. (ENGLAND) 13 (20): 4831–9. ISSN 0261-4189. PMID 7957052.  
  5. ^ a b c d e Goardon, Nicolas; Lambert Julie A, Rodriguez Patrick, Nissaire Philippe, Herblot Sabine, Thibault Pierre, Dumenil Dominique, Strouboulis John, Romeo Paul-Henri, Hoang Trang (Jan. 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. (England) 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. ISSN 0261-4189. PMID 16407974.  
  6. ^ Huang, S; Brandt S J (Mar. 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. (UNITED STATES) 20 (6): 2248–59. ISSN 0270-7306. PMID 10688671.  
  7. ^ a b Osada, H; Grutz G, Axelson H, Forster A, Rabbitts T H (Oct. 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (21): 9585–9. ISSN 0027-8424. PMID 7568177.  
  8. ^ Lécuyer, Eric; Herblot Sabine, Saint-Denis Marianne, Martin Richard, Begley C Glenn, Porcher Catherine, Orkin Stuart H, Hoang Trang (Oct. 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood (United States) 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. ISSN 0006-4971. PMID 12239153.  
  9. ^ Hsu, H L; Wadman I, Baer R (Apr. 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (8): 3181–5. ISSN 0027-8424. PMID 8159721.  
  10. ^ Huang, S; Qiu Y, Stein R W, Brandt S J (Sep. 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene (ENGLAND) 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. ISSN 0950-9232. PMID 10490830.  

Further reading

  • Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors.". Int. J. Cell Cloning 10 (5): 269–76. PMID 1453013.  
  • Aplan PD, Lombardi DP, Reaman GH, et al. (1992). "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.". Blood 79 (5): 1327–33. PMID 1311214.  
  • Aplan PD, Nakahara K, Orkin SH, Kirsch IR (1992). "The SCL gene product: a positive regulator of erythroid differentiation.". Embo J. 11 (11): 4073–81. PMID 1396592.  
  • Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein.". Blood 80 (11): 2858–66. PMID 1450410.  
  • Bernard O, Lecointe N, Jonveaux P, et al. (1991). "Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene.". Oncogene 6 (8): 1477–88. PMID 1886719.  
  • Bernard O, Guglielmi P, Jonveaux P, et al. (1991). "Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias.". Genes Chromosomes Cancer 1 (3): 194–208. doi:10.1002/gcc.2870010303. PMID 1964581.  
  • Chen Q, Yang CY, Tsan JT, et al. (1990). "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.". J. Exp. Med. 172 (5): 1403–8. doi:10.1084/jem.172.5.1403. PMID 2230650.  
  • Aplan PD, Begley CG, Bertness V, et al. (1991). "The SCL gene is formed from a transcriptionally complex locus.". Mol. Cell. Biol. 10 (12): 6426–35. PMID 2247063.  
  • Chen Q, Cheng JT, Tasi LH, et al. (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.". Embo J. 9 (2): 415–24. PMID 2303035.  
  • Begley CG, Aplan PD, Denning SM, et al. (1990). "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 10128–32. doi:10.1073/pnas.86.24.10128. PMID 2602361.  
  • Osada H, Grutz G, Axelson H, et al. (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMID 7568177.  
  • Pulford K, Lecointe N, Leroy-Viard K, et al. (1995). "Expression of TAL-1 proteins in human tissues.". Blood 85 (3): 675–84. PMID 7833471.  
  • Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". Embo J. 13 (20): 4831–9. PMID 7957052.  
  • Valge-Archer VE, Osada H, Warren AJ, et al. (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMID 8078932.  
  • Cross MA, Heyworth CM, Murrell AM, et al. (1994). "Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line.". Oncogene 9 (10): 3013–6. PMID 8084606.  
  • Hsu HL, Wadman I, Baer R (1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. PMID 8159721.  
  • Hwang LY, Siegelman M, Davis L, et al. (1993). "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen.". Oncogene 8 (11): 3043–6. PMID 8414504.  
  • Cheng JT, Cobb MH, Baer R (1993). "Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.". Mol. Cell. Biol. 13 (2): 801–8. PMID 8423803.  

External links

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