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Taste receptor, type 1, member 1
Symbols TAS1R1; TR1; GPR70; T1R1; gm148
External IDs OMIM606225 MGI1927505 HomoloGene12888 GeneCards: TAS1R1 Gene
Species Human Mouse
Entrez 80835 110326
Ensembl ENSG00000173662 ENSMUSG00000028950
UniProt Q7RTX1 Q3U5H1
RefSeq (mRNA) NM_138697 NM_031867
RefSeq (protein) NP_619642 NP_114073
Location (UCSC) Chr 1:
6.54 - 6.56 Mb
Chr 4:
150.87 - 150.88 Mb
PubMed search [1] [2]

Taste receptor type 1 member 1 is a protein that in humans is encoded by the TAS1R1 gene.[1]

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding several different isoforms have been found for this gene.[1]

See also


Further reading

  • Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste.". Nature 444 (7117): 288–94. doi:10.1038/nature05401. PMID 17108952.  
  • Hoon MA, Adler E, Lindemeier J, et al. (1999). "Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity.". Cell 96 (4): 541–51. doi:10.1016/S0092-8674(00)80658-3. PMID 10052456.  
  • Makalowska I, Sood R, Faruque MU, et al. (2002). "Identification of six novel genes by experimental validation of GeneMachine predicted genes.". Gene 284 (1-2): 203–13. doi:10.1016/S0378-1119(01)00897-6. PMID 11891061.  
  • Nelson G, Chandrashekar J, Hoon MA, et al. (2002). "An amino-acid taste receptor.". Nature 416 (6877): 199–202. doi:10.1038/nature726. PMID 11894099.  
  • Li X, Staszewski L, Xu H, et al. (2002). "Human receptors for sweet and umami taste.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. doi:10.1073/pnas.072090199. PMID 11917125.  
  • Liao J, Schultz PG (2003). "Three sweet receptor genes are clustered in human chromosome 1.". Mamm. Genome 14 (5): 291–301. doi:10.1007/s00335-002-2233-0. PMID 12856281.  
  • Xu H, Staszewski L, Tang H, et al. (2005). "Different functional roles of T1R subunits in the heteromeric taste receptors.". Proc. Natl. Acad. Sci. U.S.A. 101 (39): 14258–63. doi:10.1073/pnas.0404384101. PMID 15353592.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  
  • Sainz E, Cavenagh MM, LopezJimenez ND, et al. (2007). "The G-protein coupling properties of the human sweet and amino acid taste receptors.". Dev Neurobiol 67 (7): 948–59. doi:10.1002/dneu.20403. PMID 17506496.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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