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Taste receptor, type 1, member 2
Symbols TAS1R2; TR2; GPR71; T1R2
External IDs OMIM606226 MGI1933546 HomoloGene75323 GeneCards: TAS1R2 Gene
RNA expression pattern
PBB GE TAS1R2 gnf1h06475 at tn.png
More reference expression data
Species Human Mouse
Entrez 80834 83770
Ensembl ENSG00000179002 n/a
UniProt Q8TE23 n/a
RefSeq (mRNA) NM_152232 XM_980714
RefSeq (protein) NP_689418 XP_985808
Location (UCSC) Chr 1:
19.04 - 19.06 Mb
PubMed search [1] [2]

Taste receptor type 1 member 2 is a protein that in humans is encoded by the TAS1R2 gene.[1] A mutation in this gene gives cats the inability to taste sugar.[2 ][3]

See also


Further reading

  • Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste.". Nature 444 (7117): 288–94. doi:10.1038/nature05401. PMID 17108952.  
  • Hoon MA, Adler E, Lindemeier J, et al. (1999). "Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity.". Cell 96 (4): 541–51. doi:10.1016/S0092-8674(00)80658-3. PMID 10052456.  
  • Li X, Staszewski L, Xu H, et al. (2002). "Human receptors for sweet and umami taste.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. doi:10.1073/pnas.072090199. PMID 11917125.  
  • Spadaccini R, Trabucco F, Saviano G, et al. (2003). "The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI.". J. Mol. Biol. 328 (3): 683–92. doi:10.1016/S0022-2836(03)00346-2. PMID 12706725.  
  • Liao J, Schultz PG (2003). "Three sweet receptor genes are clustered in human chromosome 1.". Mamm. Genome 14 (5): 291–301. doi:10.1007/s00335-002-2233-0. PMID 12856281.  
  • Zhao GQ, Zhang Y, Hoon MA, et al. (2004). "The receptors for mammalian sweet and umami taste.". Cell 115 (3): 255–66. doi:10.1016/S0092-8674(03)00844-4. PMID 14636554.  
  • Galindo-Cuspinera V, Winnig M, Bufe B, et al. (2006). "A TAS1R receptor-based explanation of sweet 'water-taste'.". Nature 441 (7091): 354–7. doi:10.1038/nature04765. PMID 16633339.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  
  • Behrens M, Bartelt J, Reichling C, et al. (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression.". J. Biol. Chem. 281 (29): 20650–9. doi:10.1074/jbc.M513637200. PMID 16720576.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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