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Taste receptor, type 1, member 3
Symbols TAS1R3; T1R3
External IDs OMIM605865 MGI1933547 HomoloGene12890 GeneCards: TAS1R3 Gene
Species Human Mouse
Entrez 83756 83771
Ensembl ENSG00000169962 ENSMUSG00000029072
UniProt Q7RTX0 Q925D8
RefSeq (mRNA) NM_152228 NM_031872
RefSeq (protein) NP_689414 NP_114078
Location (UCSC) Chr 1:
1.26 - 1.26 Mb
Chr 4:
154.7 - 154.71 Mb
PubMed search [1] [2]

Taste receptor type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene.[1][2]

The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.[supplied by OMIM][2]

See also


  1. ^ Montmayeur JP, Liberles SD, Matsunami H, Buck LB (Apr 2001). "A candidate taste receptor gene near a sweet taste locus". Nat Neurosci 4 (5): 492-8. doi:10.1038/87440. PMID 11319557.  
  2. ^ a b "Entrez Gene: TAS1R3 taste receptor, type 1, member 3".  

Further reading

  • Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste.". Nature 444 (7117): 288–94. doi:10.1038/nature05401. PMID 17108952.  
  • Max M, Shanker YG, Huang L, et al. (2001). "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.". Nat. Genet. 28 (1): 58–63. doi:10.1038/88270. PMID 11326277.  
  • Nelson G, Chandrashekar J, Hoon MA, et al. (2002). "An amino-acid taste receptor.". Nature 416 (6877): 199–202. doi:10.1038/nature726. PMID 11894099.  
  • Li X, Staszewski L, Xu H, et al. (2002). "Human receptors for sweet and umami taste.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. doi:10.1073/pnas.072090199. PMID 11917125.  
  • Spadaccini R, Trabucco F, Saviano G, et al. (2003). "The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI.". J. Mol. Biol. 328 (3): 683–92. doi:10.1016/S0022-2836(03)00346-2. PMID 12706725.  
  • Ariyasu T, Matsumoto S, Kyono F, et al. (2004). "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.". In Vitro Cell. Dev. Biol. Anim. 39 (1-2): 80–8. doi:10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2. PMID 12892531.  
  • Jiang P, Ji Q, Liu Z, et al. (2004). "The cysteine-rich region of T1R3 determines responses to intensely sweet proteins.". J. Biol. Chem. 279 (43): 45068–75. doi:10.1074/jbc.M406779200. PMID 15299024.  
  • Xu H, Staszewski L, Tang H, et al. (2005). "Different functional roles of T1R subunits in the heteromeric taste receptors.". Proc. Natl. Acad. Sci. U.S.A. 101 (39): 14258–63. doi:10.1073/pnas.0404384101. PMID 15353592.  
  • Taniguchi K (2005). "Expression of the sweet receptor protein, T1R3, in the human liver and pancreas.". J. Vet. Med. Sci. 66 (11): 1311–4. doi:10.1292/jvms.66.1311. PMID 15585941.  
  • Jiang P, Cui M, Zhao B, et al. (2005). "Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.". J. Biol. Chem. 280 (15): 15238–46. doi:10.1074/jbc.M414287200. PMID 15668251.  
  • Galindo-Cuspinera V, Winnig M, Bufe B, et al. (2006). "A TAS1R receptor-based explanation of sweet 'water-taste'.". Nature 441 (7091): 354–7. doi:10.1038/nature04765. PMID 16633339.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  
  • Behrens M, Bartelt J, Reichling C, et al. (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression.". J. Biol. Chem. 281 (29): 20650–9. doi:10.1074/jbc.M513637200. PMID 16720576.  
  • Koizumi A, Nakajima K, Asakura T, et al. (2007). "Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain.". Biochem. Biophys. Res. Commun. 358 (2): 585–9. doi:10.1016/j.bbrc.2007.04.171. PMID 17499612.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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