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Taste receptor, type 2, member 14
Symbols TAS2R14; MGC125491; MGC125492; T2R14; TRB1
External IDs OMIM604790 MGI2681298 HomoloGene87013 GeneCards: TAS2R14 Gene
Species Human Mouse
Entrez 50840 387616
Ensembl ENSG00000212127 ENSMUSG00000071147
UniProt Q9NYV8 Q7TQA4
RefSeq (mRNA) NM_023922 NM_021562
RefSeq (protein) NP_076411 NP_067537
Location (UCSC) Chr 12:
11.09 - 11.32 Mb
Chr 6:
133.02 - 133.02 Mb
PubMed search [1] [2]

Taste receptor type 2 member 14 is a protein that in humans is encoded by the TAS2R14 gene.[1][2][3]



This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, TAS2R14 responds to (-)-α-thujone, the primary neurotoxic agent in absinthe, and picrotoxin, a poison found in fishberries.[4] This gene maps to the taste receptor gene cluster on chromosome 12p13.[3]

See also


  1. ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell 100 (6): 693-702. PMID 10761934.  
  2. ^ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature 404 (6778): 601-4. doi:10.1038/35007072. PMID 10766242.  
  3. ^ a b "Entrez Gene: TAS2R14 taste receptor, type 2, member 14".  
  4. ^ Behrens, M., A. Brockhoff, C. Kuhn, B. Bufe, M. Winnig, and W. Meyerhof (2004). "The human taste receptor hTAS2R14 responds to a variety of different bitter compounds". Biochem Biophys Res Commun 319: 479-485. doi:10.1016/j.bbrc.2004.05.019 S0006291X04009714 [pii].  

Further reading

  • Kinnamon SC (2000). "A plethora of taste receptors.". Neuron 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.  
  • Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction.". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.  
  • Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste.". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.  
  • Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). "T2Rs function as bitter taste receptors.". Cell 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.". Cell 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes.". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.  
  • Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.". Genetics 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMID 15744053.  
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.  
  • Behrens M, Bartelt J, Reichling C, et al. (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression.". J. Biol. Chem. 281 (29): 20650–9. doi:10.1074/jbc.M513637200. PMID 16720576.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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