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TAS2R16: Wikis


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Taste receptor, type 2, member 16
Symbols TAS2R16; T2R16
External IDs OMIM604867 MGI2681247 HomoloGene9660 GeneCards: TAS2R16 Gene
RNA expression pattern
PBB GE TAS2R16 221444 at tn.png
More reference expression data
Species Human Mouse
Entrez 50833 387347
Ensembl ENSG00000128519 ENSMUSG00000043865
UniProt Q9NYV7 A0AUK2
RefSeq (mRNA) NM_016945 NM_207022
RefSeq (protein) NP_058641 NP_996905
Location (UCSC) Chr 7:
122.42 - 122.42 Mb
Chr 6:
23.92 - 23.92 Mb
PubMed search [1] [2]

TAS2R16 (taste receptor, type 2, member 16) is a human gene that encodes for a receptor that may play a role in the perception of bitterness. [1][2]

Variants of this gene have been linked to an increased risk for alcohol dependence.[3]

The TAS2R16 gene is located on the long (q) arm of chromosome 7 at position 31.1 - 31.3, from base pair 122,228,764 to base pair 122,229,639.


See also


  1. ^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855.  
  2. ^ Drewnowski A (2001). "The science and complexity of bitter taste". Nutr Rev 59 (6): 163–9. PMID 11444592.  
  3. ^ Hinrichs AL, Wang JC, Bufe B, et al. (2006). "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence". Am. J. Hum. Genet. 78 (1): 103–11. doi:10.1086/499253. PMID 16385453.  

Further reading

  • Kinnamon SC (2000). "A plethora of taste receptors.". Neuron 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.  
  • Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction.". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.  
  • Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste.". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.  
  • Adler E, Hoon MA, Mueller KL, et al. (2000). "A novel family of mammalian taste receptors.". Cell 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.  
  • Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). "T2Rs function as bitter taste receptors.". Cell 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.  
  • Firestein S (2000). "The good taste of genomics.". Nature 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221.  
  • Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse.". Nature 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.  
  • Bufe B, Hofmann T, Krautwurst D, et al. (2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.". Nat. Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.". Cell 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes.". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.  
  • Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.". Genetics 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMID 15744053.  
  • Mueller KL, Hoon MA, Erlenbach I, et al. (2005). "The receptors and coding logic for bitter taste.". Nature 434 (7030): 225–9. doi:10.1038/nature03352. PMID 15759003.  
  • Hinrichs AL, Wang JC, Bufe B, et al. (2006). "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.". Am. J. Hum. Genet. 78 (1): 103–11. doi:10.1086/499253. PMID 16385453.  
  • Behrens M, Bartelt J, Reichling C, et al. (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression.". J. Biol. Chem. 281 (29): 20650–9. doi:10.1074/jbc.M513637200. PMID 16720576.  

External links



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