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Taste receptor, type 2, member 8
Symbols TAS2R8; T2R8; TRB5
External IDs OMIM604794 HomoloGene88894 GeneCards: TAS2R8 Gene
RNA expression pattern
PBB GE TAS2R8 221398 at tn.png
More reference expression data
Species Human Mouse
Entrez 50836 n/a
Ensembl ENSG00000121314 n/a
UniProt Q9NYW2 n/a
RefSeq (mRNA) NM_023918 n/a
RefSeq (protein) NP_076407 n/a
Location (UCSC) Chr 12:
10.85 - 10.85 Mb
PubMed search [1] n/a

Taste receptor type 2 member 8 is a protein that in humans is encoded by the TAS2R8 gene.[1][2][3]

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.[3]

See also


  1. ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell 100 (6): 693-702. PMID 10761934.  
  2. ^ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature 404 (6778): 601-4. doi:10.1038/35007072. PMID 10766242.  
  3. ^ a b "Entrez Gene: TAS2R8 taste receptor, type 2, member 8".  

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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