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TBP-like 1
Symbols TBPL1; TRF2; MGC:8389; MGC:9620; STUD; TLF; TLP
External IDs OMIM605521 MGI1339946 HomoloGene3577 GeneCards: TBPL1 Gene
RNA expression pattern
PBB GE TBPL1 208398 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9519 237336
Ensembl ENSG00000028839 ENSMUSG00000071359
UniProt P62380 P62340
RefSeq (mRNA) NM_004865 NM_011603
RefSeq (protein) NP_004856 NP_035733
Location (UCSC) Chr 6:
134.32 - 134.35 Mb
Chr 10:
22.39 - 22.42 Mb
PubMed search [1] [2]

TATA box-binding protein-like protein 1 is a protein that in humans is encoded by the TBPL1 gene.[1][2][3][4]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.[4]



TBPL1 has been shown to interact with GTF2A1.[5][6]


  1. ^ Ohbayashi T, Kishimoto T, Makino Y, Shimada M, Nakadai T, Aoki T, Kawata T, Niwa S, Tamura T (Dec 1999). "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein". Biochem Biophys Res Commun 255 (1): 137–42. PMID 10082669.  
  2. ^ Rabenstein MD, Zhou S, Lis JT, Tjian R (Jun 1999). "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family". Proc Natl Acad Sci U S A 96 (9): 4791–6. PMID 10220372.  
  3. ^ Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE (Mar 2005). "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP". Mol Cell Biol 25 (7): 2632–43. doi:10.1128/MCB.25.7.2632-2643.2005. PMID 15767669.  
  4. ^ a b "Entrez Gene: TBPL1 TBP-like 1".  
  5. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3: 89. doi:10.1038/msb4100134. PMID 17353931.  
  6. ^ Teichmann, M; Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait B T, Roeder R G (Nov. 1999). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (24): 13720–5. ISSN 0027-8424. PMID 10570139.  

Further reading

  • Ohbayashi T, Makino Y, Tamura TA (1999). "Identification of a mouse TBP-like protein (TLP) distantly related to the drosophila TBP-related factor.". Nucleic Acids Res. 27 (3): 750–5. doi:10.1093/nar/27.3.750. PMID 9889269.  
  • Teichmann M, Wang Z, Martinez E, et al. (2000). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (24): 13720–5. doi:10.1073/pnas.96.24.13720. PMID 10570139.  
  • Martianov I, Brancorsini S, Gansmuller A, et al. (2002). "Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids.". Development 129 (4): 945–55. PMID 11861477.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Kieffer-Kwon P, Martianov I, Davidson I (2005). "Cell-specific nucleolar localization of TBP-related factor 2.". Mol. Biol. Cell 15 (10): 4356–68. doi:10.1091/mbc.E04-02-0138. PMID 15269281.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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