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Symbol TBR1
Entrez 10716
HUGO 11590
OMIM 604616
RefSeq NM_006593
UniProt Q16650
Other data
Locus Chr. 2 q24.2

T-box, brain, 1 also known as TBR1 is a transcription factor of T-box family. TBR1 was identified in 1995.[1] Human and murine TBR1 proteins have similar structure and are both highly homologous to the product of Brachyury gene. In humans, the TBR1 protein is encoded by the TBR1 gene.[1]

TBR1 may act in tandem with CASK to control transcription of T-element-containing genes, including RELN and GRIN2B.[2] Targeted disruption of TBR1 in mice leads to reeler-like cortical phenotype.[3]

See also


  1. ^ a b Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L, Rubenstein JL (July 1995). "T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex". Neuron 15 (1): 63–78. PMID 7619531.  
  2. ^ Wang GS, Hong CJ, Yen TY, Huang HY, Ou Y, Huang TN, Jung WG, Kuo TY, Sheng M, Wang TF, Hsueh YP (April 2004). "Transcriptional modification by a CASK-interacting nucleosome assembly protein". Neuron 42 (1): 113–28. PMID 15066269.  
  3. ^ Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL (February 2001). "Tbr1 regulates differentiation of the preplate and layer 6". Neuron 29 (2): 353–66. PMID 11239428.  


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