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From Wikipedia, the free encyclopedia

T-box 21
Symbols TBX21; T-PET; T-bet; TBET; TBLYM
External IDs OMIM604895 MGI1888984 HomoloGene8353 GeneCards: TBX21 Gene
RNA expression pattern
PBB GE TBX21 220684 at tn.png
More reference expression data
Species Human Mouse
Entrez 30009 57765
Ensembl ENSG00000073861 ENSMUSG00000001444
UniProt Q9UL17 Q3U150
RefSeq (mRNA) NM_013351 XM_977626
RefSeq (protein) NP_037483 XP_982720
Location (UCSC) Chr 17:
43.17 - 43.18 Mb
Chr 11:
96.91 - 96.93 Mb
PubMed search [1] [2]

T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene.[1]

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.[1]


Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Szabo SJ, Kim ST, Costa GL, et al. (2000). "A novel transcription factor, T-bet, directs Th1 lineage commitment.". Cell 100 (6): 655–69. doi:10.1016/S0092-8674(00)80702-3. PMID 10761931.  
  • Zhang WX, Yang SY (2001). "Cloning and characterization of a new member of the T-box gene family.". Genomics 70 (1): 41–8. doi:10.1006/geno.2000.6361. PMID 11087660.  
  • Faedo A, Ficara F, Ghiani M, et al. (2003). "Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis.". Mech. Dev. 116 (1-2): 157–60. doi:10.1016/S0925-4773(02)00114-4. PMID 12128215.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Chung HT, Kim LH, Park BL, et al. (2003). "Association analysis of novel TBX21 variants with asthma phenotypes.". Hum. Mutat. 22 (3): 257. doi:10.1002/humu.9169. PMID 12938094.  
  • Yu HR, Chang JC, Chen RF, et al. (2004). "Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T-bet/GATA-3 expression.". J. Leukoc. Biol. 74 (5): 952–8. doi:10.1189/jlb.0902474. PMID 12960249.  
  • Lametschwandtner G, Biedermann T, Schwärzler C, et al. (2004). "Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities.". J. Allergy Clin. Immunol. 113 (5): 987–94. doi:10.1016/j.jaci.2004.02.004. PMID 15131585.  
  • Sasaki Y, Ihara K, Matsuura N, et al. (2004). "Identification of a novel type 1 diabetes susceptibility gene, T-bet.". Hum. Genet. 115 (3): 177–84. doi:10.1007/s00439-004-1146-2. PMID 15241679.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Tantisira KG, Hwang ES, Raby BA, et al. (2005). "TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids.". Proc. Natl. Acad. Sci. U.S.A. 101 (52): 18099–104. doi:10.1073/pnas.0408532102. PMID 15604153.  
  • Atayar C, Poppema S, Blokzijl T, et al. (2005). "Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas.". Am. J. Pathol. 166 (1): 127–34. PMID 15632006.  
  • Tong Y, Aune T, Boothby M (2005). "T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site.". Proc. Natl. Acad. Sci. U.S.A. 102 (6): 2034–9. doi:10.1073/pnas.0409510102. PMID 15684083.  
  • Dorfman DM, Hwang ES, Shahsafaei A, Glimcher LH (2005). "T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma.". Hum. Pathol. 36 (1): 10–5. doi:10.1016/j.humpath.2004.10.006. PMID 15712176.  
  • Kulkarni A, Ravi DS, Singh K, et al. (2005). "HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response.". Biochem. Biophys. Res. Commun. 329 (2): 706–12. doi:10.1016/j.bbrc.2005.02.042. PMID 15737643.  
  • Akahoshi M, Obara K, Hirota T, et al. (2005). "Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.". Hum. Genet. 117 (1): 16–26. doi:10.1007/s00439-005-1285-0. PMID 15806396.  
  • Kawana K, Kawana Y, Schust DJ (2005). "Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract.". Mol. Endocrinol. 19 (8): 2047–59. doi:10.1210/me.2004-0489. PMID 15860546.  
  • Harashima A, Matsuo Y, Drexler HG, et al. (2005). "Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet.". Leuk. Res. 29 (7): 841–8. doi:10.1016/j.leukres.2004.12.010. PMID 15927679.  
  • Raby BA, Hwang ES, Van Steen K, et al. (2006). "T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.". Am. J. Respir. Crit. Care Med. 173 (1): 64–70. doi:10.1164/rccm.200503-505OC. PMID 16179640.  

External links



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