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T-box 21
Identifiers
Symbols TBX21; T-PET; T-bet; TBET; TBLYM
External IDs OMIM604895 MGI1888984 HomoloGene8353 GeneCards: TBX21 Gene
RNA expression pattern
PBB GE TBX21 220684 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 30009 57765
Ensembl ENSG00000073861 ENSMUSG00000001444
UniProt Q9UL17 Q3U150
RefSeq (mRNA) NM_013351 XM_977626
RefSeq (protein) NP_037483 XP_982720
Location (UCSC) Chr 17:
43.17 - 43.18 Mb
Chr 11:
96.91 - 96.93 Mb
PubMed search [1] [2]

T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene.[1]

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.[1]

References

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Szabo SJ, Kim ST, Costa GL, et al. (2000). "A novel transcription factor, T-bet, directs Th1 lineage commitment.". Cell 100 (6): 655–69. doi:10.1016/S0092-8674(00)80702-3. PMID 10761931.  
  • Zhang WX, Yang SY (2001). "Cloning and characterization of a new member of the T-box gene family.". Genomics 70 (1): 41–8. doi:10.1006/geno.2000.6361. PMID 11087660.  
  • Faedo A, Ficara F, Ghiani M, et al. (2003). "Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis.". Mech. Dev. 116 (1-2): 157–60. doi:10.1016/S0925-4773(02)00114-4. PMID 12128215.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Chung HT, Kim LH, Park BL, et al. (2003). "Association analysis of novel TBX21 variants with asthma phenotypes.". Hum. Mutat. 22 (3): 257. doi:10.1002/humu.9169. PMID 12938094.  
  • Yu HR, Chang JC, Chen RF, et al. (2004). "Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T-bet/GATA-3 expression.". J. Leukoc. Biol. 74 (5): 952–8. doi:10.1189/jlb.0902474. PMID 12960249.  
  • Lametschwandtner G, Biedermann T, Schwärzler C, et al. (2004). "Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities.". J. Allergy Clin. Immunol. 113 (5): 987–94. doi:10.1016/j.jaci.2004.02.004. PMID 15131585.  
  • Sasaki Y, Ihara K, Matsuura N, et al. (2004). "Identification of a novel type 1 diabetes susceptibility gene, T-bet.". Hum. Genet. 115 (3): 177–84. doi:10.1007/s00439-004-1146-2. PMID 15241679.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Tantisira KG, Hwang ES, Raby BA, et al. (2005). "TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids.". Proc. Natl. Acad. Sci. U.S.A. 101 (52): 18099–104. doi:10.1073/pnas.0408532102. PMID 15604153.  
  • Atayar C, Poppema S, Blokzijl T, et al. (2005). "Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas.". Am. J. Pathol. 166 (1): 127–34. PMID 15632006.  
  • Tong Y, Aune T, Boothby M (2005). "T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site.". Proc. Natl. Acad. Sci. U.S.A. 102 (6): 2034–9. doi:10.1073/pnas.0409510102. PMID 15684083.  
  • Dorfman DM, Hwang ES, Shahsafaei A, Glimcher LH (2005). "T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma.". Hum. Pathol. 36 (1): 10–5. doi:10.1016/j.humpath.2004.10.006. PMID 15712176.  
  • Kulkarni A, Ravi DS, Singh K, et al. (2005). "HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response.". Biochem. Biophys. Res. Commun. 329 (2): 706–12. doi:10.1016/j.bbrc.2005.02.042. PMID 15737643.  
  • Akahoshi M, Obara K, Hirota T, et al. (2005). "Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.". Hum. Genet. 117 (1): 16–26. doi:10.1007/s00439-005-1285-0. PMID 15806396.  
  • Kawana K, Kawana Y, Schust DJ (2005). "Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract.". Mol. Endocrinol. 19 (8): 2047–59. doi:10.1210/me.2004-0489. PMID 15860546.  
  • Harashima A, Matsuo Y, Drexler HG, et al. (2005). "Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet.". Leuk. Res. 29 (7): 841–8. doi:10.1016/j.leukres.2004.12.010. PMID 15927679.  
  • Raby BA, Hwang ES, Van Steen K, et al. (2006). "T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.". Am. J. Respir. Crit. Care Med. 173 (1): 64–70. doi:10.1164/rccm.200503-505OC. PMID 16179640.  

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