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TC-1698: Wikis


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Systematic (IUPAC) name
ATC code  ?
PubChem 10130417
Chemical data
Formula C13H18N2 
Mol. mass 202.295
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Legal

TC-1698 is a drug developed by Targacept which acts as a partial agonist for the α7 subtype of neural nicotinic acetylcholine receptors.[1] It has neuroprotective effects in animal studies,[2] and has been used as a lead compound to find further potent derivatives.[3]


  1. ^ Romanelli, M.; Gratteri, P.; Guandalini, L.; Martini, E.; Bonaccini, C.; Gualtieri, F. (2007). "Central nicotinic receptors: structure, function, ligands, and therapeutic potential". ChemMedChem 2 (6): 746–767. doi:10.1002/cmdc.200600207. PMID 17295372.  edit
  2. ^ Marrero, M.; Papke, R.; Bhatti, B.; Shaw, S.; Bencherif, M. (2004). "The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo3.2.2nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase". The Journal of pharmacology and experimental therapeutics 309 (1): 16–27. doi:10.1124/jpet.103.061655. PMID 14722323.  edit
  3. ^ Bhatti, B.; Strachan, J.; Breining, S.; Miller, C.; Tahiri, P.; Crooks, P.; Deo, N.; Day, C. et al. (2008). "Synthesis of 2-(pyridin-3-yl)-1-azabicyclo3.2.2nonane, 2-(pyridin-3-yl)-1-azabicyclo2.2.2octane, and 2-(pyridin-3-yl)-1-azabicyclo3.2.1octane, a class of potent nicotinic acetylcholine receptor-ligands". The Journal of organic chemistry 73 (9): 3497–3507. doi:10.1021/jo800028q. PMID 18363376.  edit


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