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TDIQ: Wikis


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Systematic (IUPAC) name
CAS number 15052-05-8
ATC code  ?
PubChem 2752332
Chemical data
Formula C 10H11NO2  
Mol. mass 177.199
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

TDIQ (also known as 6,7-Methylenedioxy-1,2,3,4-tetrahydroisoquinoline or MDTHIQ) is a drug used in scientific research, which has anxiolytic and anorectic effects in animals.[1][2] It has an unusual effects profile in animals, with the effects generalising to cocaine and partially to MDMA and ephedrine,[3] but the effects did not generalise to amphetamine and TDIQ does not have any stimulant effects.[4] It is thought these effects are mediated via a partial agonist action at Alpha-2 adrenergic receptors, and TDIQ has been suggested as a possible drug for the treatment of cocaine dependence.[5]

See also


  1. ^ Young R, Rothman RB, Rangisetty JB, Partilla JS, Dukat M, Glennon RA (May 2006). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) inhibits the consumption of "snacks" in mice". Pharmacology, Biochemistry, and Behavior 84 (1): 74–83. doi:10.1016/j.pbb.2006.04.007. PMID 16750261.  
  2. ^ Young R, Batkai S, Dukat M, Glennon RA (May 2006). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) exhibits anxiolytic-like activity in a marble-burying assay in mice". Pharmacology, Biochemistry, and Behavior 84 (1): 62–73. doi:10.1016/j.pbb.2006.04.006. PMID 16750844.  
  3. ^ Young R, Glennon RA (2002). "The stimulus effect of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline is similar to that of cocaine but different from that of amphetamine". Pharmacology, Biochemistry, and Behavior 71 (1-2): 205–13. PMID 11812524.  
  4. ^ Glennon RA, Young R, Rangisetty JB (May 2002). "Further characterization of the stimulus properties of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline". Pharmacology, Biochemistry, and Behavior 72 (1-2): 379–87. PMID 11900809.  
  5. ^ Young R (2007). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo [4,5-g]isoquinoline): discovery, pharmacological effects, and therapeutic potential". CNS Drug Reviews 13 (4): 405–22. doi:10.1111/j.1527-3458.2007.00022.x. PMID 18078426.  


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