The Full Wiki

More info on TDIQ

TDIQ: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

TDIQ
Systematic (IUPAC) name
5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
Identifiers
CAS number 15052-05-8
ATC code  ?
PubChem 2752332
Chemical data
Formula C 10H11NO2  
Mol. mass 177.199
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

TDIQ (also known as 6,7-Methylenedioxy-1,2,3,4-tetrahydroisoquinoline or MDTHIQ) is a drug used in scientific research, which has anxiolytic and anorectic effects in animals.[1][2] It has an unusual effects profile in animals, with the effects generalising to cocaine and partially to MDMA and ephedrine,[3] but the effects did not generalise to amphetamine and TDIQ does not have any stimulant effects.[4] It is thought these effects are mediated via a partial agonist action at Alpha-2 adrenergic receptors, and TDIQ has been suggested as a possible drug for the treatment of cocaine dependence.[5]

See also

References

  1. ^ Young R, Rothman RB, Rangisetty JB, Partilla JS, Dukat M, Glennon RA (May 2006). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) inhibits the consumption of "snacks" in mice". Pharmacology, Biochemistry, and Behavior 84 (1): 74–83. doi:10.1016/j.pbb.2006.04.007. PMID 16750261.  
  2. ^ Young R, Batkai S, Dukat M, Glennon RA (May 2006). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) exhibits anxiolytic-like activity in a marble-burying assay in mice". Pharmacology, Biochemistry, and Behavior 84 (1): 62–73. doi:10.1016/j.pbb.2006.04.006. PMID 16750844.  
  3. ^ Young R, Glennon RA (2002). "The stimulus effect of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline is similar to that of cocaine but different from that of amphetamine". Pharmacology, Biochemistry, and Behavior 71 (1-2): 205–13. PMID 11812524.  
  4. ^ Glennon RA, Young R, Rangisetty JB (May 2002). "Further characterization of the stimulus properties of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline". Pharmacology, Biochemistry, and Behavior 72 (1-2): 379–87. PMID 11900809.  
  5. ^ Young R (2007). "TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo [4,5-g]isoquinoline): discovery, pharmacological effects, and therapeutic potential". CNS Drug Reviews 13 (4): 405–22. doi:10.1111/j.1527-3458.2007.00022.x. PMID 18078426.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message