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TEAD1: Wikis


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TEA domain family member 1 (SV40 transcriptional enhancer factor)

PDB rendering based on 2hzd.
Available structures
Symbols TEAD1; REF1; AA; TCF13; TEF-1
External IDs OMIM189967 MGI101876 HomoloGene2418 GeneCards: TEAD1 Gene
Species Human Mouse
Entrez 7003 21676
Ensembl ENSG00000187079 ENSMUSG00000055320
UniProt P28347 Q3UFP5
RefSeq (mRNA) NM_021961 NM_009346
RefSeq (protein) NP_068780 NP_033372
Location (UCSC) Chr 11:
12.72 - 12.92 Mb
Chr 7:
112.47 - 112.69 Mb
PubMed search [1] [2]

Transcriptional enhancer factor TEF-1 is a protein that in humans is encoded by the TEAD1 gene.[1][2][3][4]


TEAD1 has been shown to interact with MEF2C,[5] Serum response factor[6] and MAX.[7]


  1. ^ Xiao JH, Davidson I, Matthes H, Garnier JM, Chambon P (Jun 1991). "Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1". Cell 65 (4): 551–68. PMID 1851669.  
  2. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Mar 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.  
  3. ^ Fossdal R, Jonasson F, Kristjansdottir GT, Kong A, Stefansson H, Gosh S, Gulcher JR, Stefansson K (Apr 2004). "A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration)". Hum Mol Genet 13 (9): 975–81. doi:10.1093/hmg/ddh106. PMID 15016762.  
  4. ^ "Entrez Gene: TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)".  
  5. ^ Maeda, Tomoji; Gupta Mahesh P, Stewart Alexandre F R (Jun. 2002). "TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters". Biochem. Biophys. Res. Commun. (United States) 294 (4): 791–7. doi:10.1016/S0006-291X(02)00556-9. ISSN 0006-291X. PMID 12061776.  
  6. ^ Gupta, M; Kogut P, Davis F J, Belaguli N S, Schwartz R J, Gupta M P (Mar. 2001). "Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1". J. Biol. Chem. (United States) 276 (13): 10413–22. doi:10.1074/jbc.M008625200. ISSN 0021-9258. PMID 11136726.  
  7. ^ Gupta, M P; Amin C S, Gupta M, Hay N, Zak R (Jul. 1997). "Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression". Mol. Cell. Biol. (UNITED STATES) 17 (7): 3924–36. ISSN 0270-7306. PMID 9199327.  

Further reading

  • Boam DS, Davidson I, Chambon P (1995). "A TATA-less promoter containing binding sites for ubiquitous transcription factors mediates cell type-specific regulation of the gene for transcription enhancer factor-1 (TEF-1).". J. Biol. Chem. 270 (33): 19487–94. doi:10.1074/jbc.270.33.19487. PMID 7642633.  
  • Fossdal R, Magnússon L, Weber JL, Jensson O (1995). "Mapping the locus of atrophia areata, a helicoid peripapillary chorioretinal degeneration with autosomal dominant inheritance, to chromosome 11p15.". Hum. Mol. Genet. 4 (3): 479–83. doi:10.1093/hmg/4.3.479. PMID 7795606.  
  • Kariya K, Farrance IK, Simpson PC (1994). "Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1-adrenergic- and beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter.". J. Biol. Chem. 268 (35): 26658–62. PMID 8253797.  
  • Shimizu N, Smith G, Izumo S (1993). "Both a ubiquitous factor mTEF-1 and a distinct muscle-specific factor bind to the M-CAT motif of the myosin heavy chain beta gene.". Nucleic Acids Res. 21 (17): 4103–10. doi:10.1093/nar/21.17.4103. PMID 8396764.  
  • Stewart AF, Richard CW, Suzow J, et al. (1997). "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family.". Genomics 37 (1): 68–76. doi:10.1006/geno.1996.0522. PMID 8921372.  
  • Gupta MP, Amin CS, Gupta M, et al. (1997). "Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression.". Mol. Cell. Biol. 17 (7): 3924–36. PMID 9199327.  
  • Simmonds AJ, Liu X, Soanes KH, et al. (1999). "Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila.". Genes Dev. 12 (24): 3815–20. doi:10.1101/gad.12.24.3815. PMID 9869635.  
  • Vaudin P, Delanoue R, Davidson I, et al. (1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.". Development 126 (21): 4807–16. PMID 10518497.  
  • Gupta M, Kogut P, Davis FJ, et al. (2001). "Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1.". J. Biol. Chem. 276 (13): 10413–22. doi:10.1074/jbc.M008625200. PMID 11136726.  
  • Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMID 11358867.  
  • Carlini LE, Getz MJ, Strauch AR, Kelm RJ (2002). "Cryptic MCAT enhancer regulation in fibroblasts and smooth muscle cells. Suppression of TEF-1 mediated activation by the single-stranded DNA-binding proteins, Pur alpha, Pur beta, and MSY1.". J. Biol. Chem. 277 (10): 8682–92. doi:10.1074/jbc.M109754200. PMID 11751932.  
  • Maeda T, Gupta MP, Stewart AF (2002). "TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters.". Biochem. Biophys. Res. Commun. 294 (4): 791–7. doi:10.1016/S0006-291X(02)00556-9. PMID 12061776.  
  • Maeda T, Chapman DL, Stewart AF (2003). "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation.". J. Biol. Chem. 277 (50): 48889–98. doi:10.1074/jbc.M206858200. PMID 12376544.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Thompson M, Andrade VA, Andrade SJ, et al. (2003). "Inhibition of the TEF/TEAD transcription factor activity by nuclear calcium and distinct kinase pathways.". Biochem. Biophys. Res. Commun. 301 (2): 267–74. doi:10.1016/S0006-291X(02)03024-3. PMID 12565854.  
  • Karasseva N, Tsika G, Ji J, et al. (2003). "Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.". Mol. Cell. Biol. 23 (15): 5143–64. doi:10.1128/MCB.23.15.5143-5164.2003. PMID 12861002.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Günther S, Mielcarek M, Krüger M, Braun T (2004). "VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation.". Nucleic Acids Res. 32 (2): 791–802. doi:10.1093/nar/gkh248. PMID 14762206.  


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