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TEA domain family member 3

PDB rendering based on 2hzd.
Available structures
Symbols TEAD3; DTEF-1; ETFR-1; TEAD5; TEF-5; TEF5
External IDs OMIM603170 MGI109241 HomoloGene81821 GeneCards: TEAD3 Gene
RNA expression pattern
PBB GE TEAD3 209454 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7005 21678
Ensembl ENSG00000007866 ENSMUSG00000002249
UniProt Q99594 Q80V67
RefSeq (mRNA) NM_003214 NM_011566
RefSeq (protein) NP_003205 NP_035696
Location (UCSC) Chr 6:
35.55 - 35.57 Mb
Chr 17:
28.06 - 28.08 Mb
PubMed search [1] [2]

Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.[1][2][3]

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon.[3]


  1. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Mar 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127-9. doi:10.1006/geno.1998.5628. PMID 9889009.  
  2. ^ Jacquemin P, Martial JA, Davidson I (Jun 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". J Biol Chem 272 (20): 12928-37. PMID 9148898.  
  3. ^ a b "Entrez Gene: TEAD3 TEA domain family member 3".  

Further reading

  • Jiang SW, Wu K, Eberhardt NL (1999). "Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer.". Mol. Endocrinol. 13 (6): 879–89. doi:10.1210/me.13.6.879. PMID 10379887.  
  • Vaudin P, Delanoue R, Davidson I, et al. (1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.". Development 126 (21): 4807–16. PMID 10518497.  
  • Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMID 11358867.  
  • Maeda T, Mazzulli JR, Farrance IK, Stewart AF (2002). "Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes.". J. Biol. Chem. 277 (27): 24346–52. doi:10.1074/jbc.M201171200. PMID 11986313.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Peng L, Huang Y, Jin F, et al. (2005). "Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1.". Mol. Endocrinol. 18 (8): 2049–60. doi:10.1210/me.2004-0028. PMID 15131259.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  

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