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TEA domain family member 4

PDB rendering based on 2hzd.
Available structures
Symbols TEAD4; EFTR-2; MGC9014; RTEF-1; RTEF1; TCF13L1; TEF-3; TEFR-1; hRTEF-1B
External IDs OMIM601714 MGI106907 HomoloGene74463 GeneCards: TEAD4 Gene
RNA expression pattern
PBB GE TEAD4 41037 at tn.png
PBB GE TEAD4 204281 at tn.png
More reference expression data
Species Human Mouse
Entrez 7004 21679
Ensembl ENSG00000197905 ENSMUSG00000030353
UniProt Q15561 Q62296
RefSeq (mRNA) NM_003213 NM_001080979
RefSeq (protein) NP_003204 NP_001074448
Location (UCSC) Chr 12:
2.94 - 3.02 Mb
Chr 6:
128.19 - 128.27 Mb
PubMed search [1] [2]

Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene.[1][2][3]

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.[3]


  1. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Mar 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127-9. doi:10.1006/geno.1998.5628. PMID 9889009.  
  2. ^ Stewart AF, Richard CW 3rd, Suzow J, Stephan D, Weremowicz S, Morton CC, Adra CN (Feb 1997). "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family". Genomics 37 (1): 68-76. PMID 8921372.  
  3. ^ a b "Entrez Gene: TEAD4 TEA domain family member 4".  

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Hsu DK, Guo Y, Alberts GF, et al. (1996). "Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation.". J. Biol. Chem. 271 (23): 13786–95. doi:10.1074/jbc.271.23.13786. PMID 8662936.  
  • Jacquemin P, Hwang JJ, Martial JA, et al. (1996). "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain.". J. Biol. Chem. 271 (36): 21775–85. doi:10.1074/jbc.271.36.21775. PMID 8702974.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Vaudin P, Delanoue R, Davidson I, et al. (1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.". Development 126 (21): 4807–16. PMID 10518497.  
  • Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMID 11358867.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Chen HH, Baty CJ, Maeda T, et al. (2005). "Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation.". Circulation 110 (19): 2980–7. doi:10.1161/01.CIR.0000146902.84099.26. PMID 15520314.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Appukuttan B, McFarland TJ, Davies MH, et al. (2007). "Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina.". Invest. Ophthalmol. Vis. Sci. 48 (8): 3775–82. doi:10.1167/iovs.06-1172. PMID 17652751.  

External links



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