TEK tyrosine kinase: Wikis


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TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)

PDB rendering based on 1fvr.
Available structures
1fvr, 2gy5, 2gy7, 2oo8, 2osc, 2p4i
Symbols TEK; CD202B; TIE-2; TIE2; VMCM; VMCM1
External IDs OMIM600221 MGI98664 HomoloGene397 GeneCards: TEK Gene
RNA expression pattern
PBB GE TEK 206702 at tn.png
PBB GE TEK 217711 at tn.png
More reference expression data
Species Human Mouse
Entrez 7010 21687
Ensembl ENSG00000120156 ENSMUSG00000006386
UniProt Q02763 Q02858
RefSeq (mRNA) NM_000459 NM_013690
RefSeq (protein) NP_000450 NP_038718
Location (UCSC) Chr 9:
27.1 - 27.22 Mb
Chr 4:
94.23 - 94.37 Mb
PubMed search [1] [2]

Angiopoietin-1 receptor is a protein that in humans is encoded by the TEK gene.[1][2]

TEK has also recently been designated CD202B (cluster of differentiation 202B).

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.[3]



TEK tyrosine kinase has been shown to interact with DOK2,[4][5] Angiopoietin 1[6][7][8][9] and ANGPT2.[6][8][9]

External Links


  1. ^ Partanen J, Armstrong E, Makela TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (Apr 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Mol Cell Biol 12 (4): 1698–707. PMID 1312667.  
  2. ^ Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (Feb 1995). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p". Hum Mol Genet 3 (9): 1583–7. PMID 7833915.  
  3. ^ "Entrez Gene: TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7010.  
  4. ^ Jones, N; Dumont D J (Sep. 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene (ENGLAND) 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. ISSN 0950-9232. PMID 9764820.  
  5. ^ Master, Z; Jones N, Tran J, Jones J, Kerbel R S, Dumont D J (Nov. 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. (England) 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. ISSN 0261-4189. PMID 11689432.  
  6. ^ a b Fiedler, Ulrike; Krissl Tanja, Koidl Stefanie, Weiss Cornelia, Koblizek Thomas, Deutsch Urban, Martiny-Baron Georg, Marmé Dieter, Augustin Hellmut G (Jan. 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. (United States) 278 (3): 1721–7. doi:10.1074/jbc.M208550200. ISSN 0021-9258. PMID 12427764.  
  7. ^ Davis, S; Aldrich T H, Jones P F, Acheson A, Compton D L, Jain V, Ryan T E, Bruno J, Radziejewski C, Maisonpierre P C, Yancopoulos G D (Dec. 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell (UNITED STATES) 87 (7): 1161–9. ISSN 0092-8674. PMID 8980221.  
  8. ^ a b Sato, A; Iwama A, Takakura N, Nishio H, Yancopoulos G D, Suda T (Aug. 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. (ENGLAND) 10 (8): 1217–27. ISSN 0953-8178. PMID 9723709.  
  9. ^ a b Maisonpierre, P C; Suri C, Jones P F, Bartunkova S, Wiegand S J, Radziejewski C, Compton D, McClain J, Aldrich T H, Papadopoulos N, Daly T J, Davis S, Sato T N, Yancopoulos G D (Jul. 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science (UNITED STATES) 277 (5322): 55–60. ISSN 0036-8075. PMID 9229772.  

Further reading

  • Huang L, Turck CW, Rao P, Peters KG (1995). "GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase.". Oncogene 11 (10): 2097–103. PMID 7478529.  
  • Deans JP, Kalt L, Ledbetter JA, et al. (1995). "Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20.". J. Biol. Chem. 270 (38): 22632–8. doi:10.1074/jbc.270.38.22632. PMID 7545683.  
  • Gallione CJ, Pasyk KA, Boon LM, et al. (1995). "A gene for familial venous malformations maps to chromosome 9p in a second large kindred.". J. Med. Genet. 32 (3): 197–9. doi:10.1136/jmg.32.3.197. PMID 7783168.  
  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.  
  • Dumont DJ, Anderson L, Breitman ML, Duncan AM (1995). "Assignment of the endothelial-specific protein receptor tyrosine kinase gene (TEK) to human chromosome 9p21.". Genomics 23 (2): 512–3. doi:10.1006/geno.1994.1536. PMID 7835909.  
  • Ziegler SF, Bird TA, Schneringer JA, et al. (1993). "Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.". Oncogene 8 (3): 663–70. PMID 8382358.  
  • Davis S, Aldrich TH, Jones PF, et al. (1997). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.". Cell 87 (7): 1161–9. doi:10.1016/S0092-8674(00)81812-7. PMID 8980223.  
  • Suri C, Jones PF, Patan S, et al. (1997). "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.". Cell 87 (7): 1171–80. doi:10.1016/S0092-8674(00)81813-9. PMID 8980224.  
  • Vikkula M, Boon LM, Carraway KL, et al. (1997). "Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.". Cell 87 (7): 1181–90. doi:10.1016/S0092-8674(00)81814-0. PMID 8980225.  
  • Witzenbichler B, Maisonpierre PC, Jones P, et al. (1998). "Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2.". J. Biol. Chem. 273 (29): 18514–21. doi:10.1074/jbc.273.29.18514. PMID 9660821.  
  • Asahara T, Chen D, Takahashi T, et al. (1998). "Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.". Circ. Res. 83 (3): 233–40. PMID 9710115.  
  • Sato A, Iwama A, Takakura N, et al. (1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells.". Int. Immunol. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.  
  • Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.". Oncogene 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID 9764820.  
  • De Sepulveda P, Okkenhaug K, Rose JL, et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.". Embo J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMID 10022833.  
  • Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. doi:10.1073/pnas.96.5.1904. PMID 10051567.  
  • Calvert JT, Riney TJ, Kontos CD, et al. (1999). "Allelic and locus heterogeneity in inherited venous malformations.". Hum. Mol. Genet. 8 (7): 1279–89. doi:10.1093/hmg/8.7.1279. PMID 10369874.  
  • Jones N, Master Z, Jones J, et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.". J. Biol. Chem. 274 (43): 30896–905. doi:10.1074/jbc.274.43.30896. PMID 10521483.  
  • Fachinger G, Deutsch U, Risau W (1999). "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2.". Oncogene 18 (43): 5948–53. doi:10.1038/sj.onc.1202992. PMID 10557082.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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