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Transcription factor AP-4 (activating enhancer binding protein 4)
Symbols TFAP4; AP-4
External IDs OMIM600743 MGI103239 HomoloGene2424 GeneCards: TFAP4 Gene
RNA expression pattern
PBB GE TFAP4 205688 at tn.png
More reference expression data
Species Human Mouse
Entrez 7023 83383
Ensembl ENSG00000090447 ENSMUSG00000005718
UniProt Q01664 n/a
RefSeq (mRNA) NM_003223 XM_978076
RefSeq (protein) NP_003214 XP_983170
Location (UCSC) Chr 16:
4.25 - 4.26 Mb
Chr 16:
4.46 - 4.47 Mb
PubMed search [1] [2]

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.[1]



Transcription factor AP4 is a member of the basic-helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.


Further reading

  • Hu YF, Lüscher B, Admon A, et al. (1991). "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.". Genes Dev. 4 (10): 1741–52. doi:10.1101/gad.4.10.1741. PMID 2123466.  
  • Mermod N, Williams TJ, Tjian R (1988). "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro.". Nature 332 (6164): 557–61. doi:10.1038/332557a0. PMID 2833704.  
  • Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.". J. Virol. 68 (11): 7188–99. PMID 7933101.  
  • Lewis TB, Wood S, Michaelis EK, et al. (1996). "Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24.". Genomics 32 (1): 131–3. doi:10.1006/geno.1996.0088. PMID 8786101.  
  • Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene.". Mol. Endocrinol. 12 (2): 233–47. doi:10.1210/me.12.2.233. PMID 9482665.  
  • King-Jones K, Korge G, Lehmann M (1999). "The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4.". J. Mol. Biol. 291 (1): 71–82. doi:10.1006/jmbi.1999.2963. PMID 10438607.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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