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From Wikipedia, the free encyclopedia

Transcription factor EB
Symbols TFEB; AlphaTFEB; TCFEB
External IDs OMIM600744 MGI103270 HomoloGene5182 GeneCards: TFEB Gene
RNA expression pattern
PBB GE TFEB 221866 at tn.png
PBB GE TFEB 50221 at tn.png
More reference expression data
Species Human Mouse
Entrez 7942 21425
Ensembl ENSG00000112561 ENSMUSG00000023990
UniProt P19484 Q3U327
RefSeq (mRNA) NM_007162 NM_011549
RefSeq (protein) NP_009093 NP_035679
Location (UCSC) Chr 6:
41.76 - 41.81 Mb
Chr 17:
47.2 - 47.26 Mb
PubMed search [1] [2]

Transcription factor EB is a protein that in humans is encoded by the TFEB gene.[1][2]


Further reading

  • Steingrímsson E, Sawadogo M, Gilbert DJ, et al. (1996). "Murine chromosomal location of five bHLH-Zip transcription factor genes.". Genomics 28 (2): 179–83. doi:10.1006/geno.1995.1129. PMID 8530024.  
  • Steingrímsson E, Tessarollo L, Reid SW, et al. (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.". Development 125 (23): 4607–16. PMID 9806910.  
  • Verastegui C, Bertolotto C, Bille K, et al. (2000). "TFE3, a transcription factor homologous to microphthalmia, is a potential transcriptional activator of tyrosinase and TyrpI genes.". Mol. Endocrinol. 14 (3): 449–56. doi:10.1210/me.14.3.449. PMID 10707962.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Davis IJ, Hsi BL, Arroyo JD, et al. (2003). "Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation.". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6051–6. doi:10.1073/pnas.0931430100. PMID 12719541.  
  • Kuiper RP, Schepens M, Thijssen J, et al. (2003). "Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution.". Hum. Mol. Genet. 12 (14): 1661–9. doi:10.1093/hmg/ddg178. PMID 12837690.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Kuiper RP, Schepens M, Thijssen J, et al. (2004). "Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains.". Nucleic Acids Res. 32 (8): 2315–22. doi:10.1093/nar/gkh571. PMID 15118077.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Argani P, Laé M, Hutchinson B, et al. (2005). "Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR.". Am. J. Surg. Pathol. 29 (2): 230–40. doi:10.1097/01.pas.0000146007.54092.37. PMID 15644781.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Pecciarini L, Cangi MG, Lo Cunsolo C, et al. (2007). "Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient.". Genes Chromosomes Cancer 46 (5): 419–26. doi:10.1002/gcc.20422. PMID 17285572.  


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