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THO complex 1

PDB rendering based on 1wxp.
Available structures
1wxp
Identifiers
Symbols THOC1; HPR1; P84; P84N5
External IDs OMIM606930 MGI1919668 HomoloGene38012 GeneCards: THOC1 Gene
RNA expression pattern
PBB GE THOC1 204064 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9984 225160
Ensembl ENSG00000079134 ENSMUSG00000024287
UniProt Q96FV9 Q3UTN0
RefSeq (mRNA) NM_005131 NM_153552
RefSeq (protein) NP_005122 NP_705780
Location (UCSC) Chr 18:
0.2 - 0.26 Mb
Chr 18:
9.96 - 10 Mb
PubMed search [1] [2]

THO complex subunit 1 is a protein that in humans is encoded by the THOC1 gene.[1][2]

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM][2]

Interactions

THOC1 has been shown to interact with Retinoblastoma protein.[3]

References

  1. ^ Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature 417 (6886): 304–8. doi:10.1038/nature746. PMID 11979277.  
  2. ^ a b "Entrez Gene: THOC1 THO complex 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9984.  
  3. ^ Durfee, T; Mancini M A, Jones D, Elledge S J, Lee W H (Nov. 1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing". J. Cell Biol. (UNITED STATES) 127 (3): 609–22. ISSN 0021-9525. PMID 7525595.  

Further reading

  • Durfee T, Mancini MA, Jones D, et al. (1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing.". J. Cell Biol. 127 (3): 609–22. doi:10.1083/jcb.127.3.609. PMID 7525595.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Dennehey BK, Gutches DG, McConkey EH, Krauter KS (2004). "Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution.". Genomics 83 (3): 493–501. doi:10.1016/j.ygeno.2003.08.017. PMID 14962675.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Gasparri F, Sola F, Locatelli G, Muzio M (2004). "The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm.". FEBS Lett. 574 (1-3): 13–9. doi:10.1016/j.febslet.2004.07.074. PMID 15358532.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Li Y, Wang X, Zhang X, Goodrich DW (2005). "Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.". Mol. Cell. Biol. 25 (10): 4023–33. doi:10.1128/MCB.25.10.4023-4033.2005. PMID 15870275.  
  • Masuda S, Das R, Cheng H, et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing.". Genes Dev. 19 (13): 1512–7. doi:10.1101/gad.1302205. PMID 15998806.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Li Y, Lin AW, Zhang X, et al. (2007). "Cancer cells and normal cells differ in their requirements for Thoc1.". Cancer Res. 67 (14): 6657–64. doi:10.1158/0008-5472.CAN-06-3234. PMID 17638875.  
  • Garner E, Martinon F, Tschopp J, et al. (2007). "Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6.". Cancer Res. 67 (16): 7631–7. doi:10.1158/0008-5472.CAN-07-0334. PMID 17699767.  
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