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Toll-like receptor 10

PDB rendering based on 2j67.
Available structures
2j67
Identifiers
Symbols TLR10; MGC104967; MGC126398; MGC126399; CD290
External IDs OMIM606270 HomoloGene12809 GeneCards: TLR10 Gene
Orthologs
Species Human Mouse
Entrez 81793 n/a
Ensembl ENSG00000174123 n/a
UniProt Q9BXR5 n/a
RefSeq (mRNA) NM_001017388 n/a
RefSeq (protein) NP_001017388 n/a
Location (UCSC) Chr 4:
38.45 - 38.46 Mb
n/a
PubMed search [1] n/a

Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene.[1] TLR10 has also been designated as CD290 (cluster of differentiation 290).

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Its exact function is not known. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[2]

References

  1. ^ Chuang T, Ulevitch RJ (Mar 2001). "Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells". Biochim Biophys Acta 1518 (1-2): 157-61. PMID 11267672.  
  2. ^ "Entrez Gene: TLR10 toll-like receptor 10". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81793.  

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