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Toll-like receptor 7
Identifiers
Symbols TLR7;
External IDs OMIM300365 MGI2176882 HomoloGene75060 GeneCards: TLR7 Gene
RNA expression pattern
PBB GE TLR7 220146 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51284 170743
Ensembl ENSG00000196664 ENSMUSG00000044583
UniProt Q9NYK1 Q3T997
RefSeq (mRNA) NM_016562 XM_989349
RefSeq (protein) NP_057646 XP_994443
Location (UCSC) Chr X:
12.8 - 12.82 Mb
Chr X:
162.65 - 162.67 Mb
PubMed search [1] [2]

Toll-like receptor 7, also known as TLR7, is an immune gene possessed by humans and other mammals and additionally in avian species.

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X.[1] Imiquimod acts upon TLR 7.[2]

TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.

References

  1. ^ "Entrez Gene: TLR7 toll-like receptor 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51284.  
  2. ^ Hemmi H, Kaisho T, Takeuchi O, et al. (2002). "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway". Nat. Immunol. 3 (2): 196–200. doi:10.1038/ni758. PMID 11812998.  

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