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tropomodulin 4 (muscle)
Symbol TMOD4
Entrez 29765
HUGO 11874
OMIM 605834
RefSeq NM_013353
UniProt Q9NZQ9
Other data
Locus Chr. 1 q12

Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.[1][2]


This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.[3]


  1. ^ Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.  
  2. ^ Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM (October 1999). "Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle". J. Biol. Chem. 274 (40): 28466–75. PMID 10497209.  
  3. ^ "Entrez Gene: TMOD4 , Tropomodulin 4 (muscle)".  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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