The Full Wiki

TNFRSF10B: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Tumor necrosis factor receptor superfamily, member 10b

PDB rendering based on 1d0g.
Available structures
1d0g, 1d4v, 1du3, 1za3, 2h9g
Identifiers
Symbols TNFRSF10B; CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9
External IDs OMIM603612 HomoloGene88698 GeneCards: TNFRSF10B Gene
RNA expression pattern
PBB GE TNFRSF10B 209295 at tn.png
PBB GE TNFRSF10B 209294 x at tn.png
PBB GE TNFRSF10B 210405 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8795 n/a
Ensembl ENSG00000120889 n/a
UniProt O14763 n/a
RefSeq (mRNA) NM_003842 n/a
RefSeq (protein) NP_003833 n/a
Location (UCSC) Chr 8:
22.93 - 22.98 Mb
n/a
PubMed search [1] n/a

Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, is a human gene. As know as; DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[1]

Contents

Interactions

TNFRSF10B has been shown to interact with FADD,[2][3] TRAIL,[4][5][6] Caspase 10[2][7] and Caspase 8.[2][7]

See also

References

  1. ^ "Entrez Gene: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8795.  
  2. ^ a b c Gajate, Consuelo; Mollinedo Faustino (Mar. 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. (United States) 280 (12): 11641–7. doi:10.1074/jbc.M411781200. ISSN 0021-9258. PMID 15659383.  
  3. ^ Chaudhary, P M; Eby M, Jasmin A, Bookwalter A, Murray J, Hood L (Dec. 1997). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway". Immunity (UNITED STATES) 7 (6): 821–30. ISSN 1074-7613. PMID 9430227.  
  4. ^ Kaptein, A; Jansen M, Dilaver G, Kitson J, Dash L, Wang E, Owen M J, Bodmer J L, Tschopp J, Farrow S N (Nov. 2000). "Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)". FEBS Lett. (NETHERLANDS) 485 (2-3): 135–41. ISSN 0014-5793. PMID 11094155.  
  5. ^ Walczak, H; Degli-Esposti M A, Johnson R S, Smolak P J, Waugh J Y, Boiani N, Timour M S, Gerhart M J, Schooley K A, Smith C A, Goodwin R G, Rauch C T (Sep. 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J. (ENGLAND) 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. ISSN 0261-4189. PMID 9311998.  
  6. ^ Hymowitz, S G; Christinger H W, Fuh G, Ultsch M, O'Connell M, Kelley R F, Ashkenazi A, de Vos A M (Oct. 1999). "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5". Mol. Cell (UNITED STATES) 4 (4): 563–71. ISSN 1097-2765. PMID 10549288.  
  7. ^ a b MacFarlane, M; Ahmad M, Srinivasula S M, Fernandes-Alnemri T, Cohen G M, Alnemri E S (Oct. 1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J. Biol. Chem. (UNITED STATES) 272 (41): 25417–20. ISSN 0021-9258. PMID 9325248.  

Further reading

  • Abe K, Kurakin A, Mohseni-Maybodi M, et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand.". Ann. N. Y. Acad. Sci. 926: 52–63. PMID 11193041.  
  • Cha SS, Song YL, Oh BH (2004). "Specificity of molecular recognition learned from the crystal structures of TRAIL and the TRAIL:sDR5 complex.". Vitam. Horm. 67: 1–17. doi:10.1016/S0083-6729(04)67001-4. PMID 15110168.  
  • Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72. doi:10.1038/sj.cr.7290236. PMID 15538968.  
  • Pan G, Ni J, Wei YF, et al. (1997). "An antagonist decoy receptor and a death domain-containing receptor for TRAIL.". Science 277 (5327): 815–8. doi:10.1126/science.277.5327.815. PMID 9242610.  
  • Sheridan JP, Marsters SA, Pitti RM, et al. (1997). "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.". Science 277 (5327): 818–21. doi:10.1126/science.277.5327.818. PMID 9242611.  
  • Screaton GR, Mongkolsapaya J, Xu XN, et al. (1998). "TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.". Curr. Biol. 7 (9): 693–6. doi:10.1016/S0960-9822(06)00297-1. PMID 9285725.  
  • Walczak H, Degli-Esposti MA, Johnson RS, et al. (1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.". Embo J. 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMID 9311998.  
  • MacFarlane M, Ahmad M, Srinivasula SM, et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.". J. Biol. Chem. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. PMID 9325248.  
  • Wu GS, Burns TF, McDonald ER, et al. (1997). "KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.". Nat. Genet. 17 (2): 141–3. doi:10.1038/ng1097-141. PMID 9326928.  
  • Schneider P, Bodmer JL, Thome M, et al. (1997). "Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34. doi:10.1016/S0014-5793(97)01231-3. PMID 9373179.  
  • Marsters SA, Sheridan JP, Pitti RM, et al. (1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain.". Curr. Biol. 7 (12): 1003–6. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840.  
  • Chaudhary PM, Eby M, Jasmin A, et al. (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.". Immunity 7 (6): 821–30. doi:10.1016/S1074-7613(00)80400-8. PMID 9430227.  
  • Schneider P, Thome M, Burns K, et al. (1998). "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.". Immunity 7 (6): 831–6. doi:10.1016/S1074-7613(00)80401-X. PMID 9430228.  
  • Pai SI, Wu GS, Ozören N, et al. (1998). "Rare loss-of-function mutation of a death receptor gene in head and neck cancer.". Cancer Res. 58 (16): 3513–8. PMID 9721851.  
  • Arai T, Akiyama Y, Okabe S, et al. (1999). "Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.". Cancer Lett. 133 (2): 197–204. doi:10.1016/S0304-3835(98)00230-4. PMID 10072170.  
  • Mongkolsapaya J, Grimes JM, Chen N, et al. (2002). "Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.". Nat. Struct. Biol. 6 (11): 1048–53. doi:10.1038/14935. PMID 10542098.  
  • Hymowitz SG, Christinger HW, Fuh G, et al. (1999). "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.". Mol. Cell 4 (4): 563–71. doi:10.1016/S1097-2765(00)80207-5. PMID 10549288.  
  • Kuang AA, Diehl GE, Zhang J, Winoto A (2000). "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts.". J. Biol. Chem. 275 (33): 25065–8. doi:10.1074/jbc.C000284200. PMID 10862756.  
  • Trauzold A, Wermann H, Arlt A, et al. (2001). "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells.". Oncogene 20 (31): 4258–69. doi:10.1038/sj.onc.1204559. PMID 11464292.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message