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TNFRSF13B: Wikis


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Tumor necrosis factor receptor superfamily, member 13B

PDB rendering based on 1xu1.
Available structures
1xu1, 1xut
Symbols TNFRSF13B; CD267; CVID; FLJ39942; MGC133214; MGC39952; TACI; TNFRSF14B
External IDs OMIM604907 MGI1889411 HomoloGene49320 GeneCards: TNFRSF13B Gene
RNA expression pattern
PBB GE TNFRSF13B 207641 at tn.png
More reference expression data
Species Human Mouse
Entrez 23495 57916
Ensembl ENSG00000108516 ENSMUSG00000010142
UniProt O14836 Q5SU82
RefSeq (mRNA) NM_012452 NM_021349
RefSeq (protein) NP_036584 NP_067324
Location (UCSC) Chr 17:
16.78 - 16.82 Mb
Chr 11:
60.94 - 60.97 Mb
PubMed search [1] [2]

Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system.[1]

TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. These proteins signal through TACI inducing activation of several transcription factors including NFAT, AP-1, and NF-kappa-B which then modulate cellular activities. Defects in the function of TACI can lead to immune system diseases.


Functions of TACI

TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis.

Medical significance

TACI mutations are associated with immunodeficiency in humans, as a significant proportion of CVID patients have TACI mutations. People with this condition produce abnormally low amounts of antibodies, which are needed for protection against infections.

In humans, the gene encoding this protein is located within the Smith-Magenis syndrome region on chromosome 17.[1]


TNFRSF13B has been shown to interact with B-cell activating factor,[2][3] TRAF6,[3] TRAF5,[3] TNFSF13,[2] TRAF2[3] and CAMLG.[3][4]


  1. ^ a b "Entrez Gene: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B".  
  2. ^ a b Wu, Y; Bressette D, Carrell J A, Kaufman T, Feng P, Taylor K, Gan Y, Cho Y H, Garcia A D, Gollatz E, Dimke D, LaFleur D, Migone T S, Nardelli B, Wei P, Ruben S M, Ullrich S J, Olsen H S, Kanakaraj P, Moore P A, Baker K P (Nov. 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". J. Biol. Chem. (UNITED STATES) 275 (45): 35478–85. doi:10.1074/jbc.M005224200. ISSN 0021-9258. PMID 10956646.  
  3. ^ a b c d e Xia, X Z; Treanor J, Senaldi G, Khare S D, Boone T, Kelley M, Theill L E, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng S Y, Boyle W J, Hsu H (Jul. 2000). "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation". J. Exp. Med. (UNITED STATES) 192 (1): 137–43. ISSN 0022-1007. PMID 10880535.  
  4. ^ von Bülow, G U; Bram R J (Oct. 1997). "NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily". Science (UNITED STATES) 278 (5335): 138–41. ISSN 0036-8075. PMID 9311921.  

Further reading

  • Bossen C, Schneider P (2007). "BAFF, APRIL and their receptors: structure, function and signaling.". Semin. Immunol. 18 (5): 263–75. doi:10.1016/j.smim.2006.04.006. PMID 16914324.  
  • Treml LS, Crowley JE, Cancro MP (2007). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin. Immunol. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.  
  • Mackay F, Leung H (2007). "The role of the BAFF/APRIL system on T cell function.". Semin. Immunol. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039.  
  • Salzer U, Jennings S, Grimbacher B (2007). "To switch or not to switch--the opposing roles of TACI in terminal B cell differentiation.". Eur. J. Immunol. 37 (1): 17–20. doi:10.1002/eji.200636914. PMID 17171762.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.  
  • von Bülow GU, Bram RJ (1997). "NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.". Science 278 (5335): 138–41. PMID 9311921.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.  
  • Gross JA, Johnston J, Mudri S, et al. (2000). "TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.". Nature 404 (6781): 995–9. doi:10.1038/35010115. PMID 10801128.  
  • Xia XZ, Treanor J, Senaldi G, et al. (2000). "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.". J. Exp. Med. 192 (1): 137–43. PMID 10880535.  
  • Yan M, Marsters SA, Grewal IS, et al. (2001). "Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity.". Nat. Immunol. 1 (1): 37–41. doi:10.1038/76889. PMID 10881172.  
  • Marsters SA, Yan M, Pitti RM, et al. (2000). "Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI.". Curr. Biol. 10 (13): 785–8. PMID 10898980.  
  • von Bülow GU, Russell H, Copeland NG, et al. (2000). "Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse.". Mamm. Genome 11 (8): 628–32. PMID 10920230.  
  • Wu Y, Bressette D, Carrell JA, et al. (2001). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS.". J. Biol. Chem. 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646.  
  • Yu G, Boone T, Delaney J, et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.". Nat. Immunol. 1 (3): 252–6. doi:10.1038/79802. PMID 10973284.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Novak AJ, Darce JR, Arendt BK, et al. (2004). "Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival.". Blood 103 (2): 689–94. doi:10.1182/blood-2003-06-2043. PMID 14512299.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Hymowitz SG, Patel DR, Wallweber HJ, et al. (2005). "Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.". J. Biol. Chem. 280 (8): 7218–27. doi:10.1074/jbc.M411714200. PMID 15542592.  
  • Moreaux J, Cremer FW, Reme T, et al. (2005). "The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature.". Blood 106 (3): 1021–30. doi:10.1182/blood-2004-11-4512. PMID 15827134.  
  • Castigli E, Wilson SA, Garibyan L, et al. (2005). "TACI is mutant in common variable immunodeficiency and IgA deficiency.". Nat. Genet. 37 (8): 829–34. doi:10.1038/ng1601. PMID 16007086.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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