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TNFRSF13C: Wikis


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Tumor necrosis factor receptor superfamily, member 13C

PDB rendering based on 1oqe.
Available structures
1oqe, 1osx, 1p0t, 2hfg
Symbols TNFRSF13C; BAFF-R; BAFFR; CD268; MGC138235
External IDs OMIM606269 MGI1919299 HomoloGene49897 GeneCards: TNFRSF13C Gene
Species Human Mouse
Entrez 115650 72049
Ensembl ENSG00000159958 ENSMUSG00000068105
UniProt Q96RJ3 Q3SXS6
RefSeq (mRNA) NM_052945 NM_028075
RefSeq (protein) NP_443177 NP_082351
Location (UCSC) Chr 22:
40.65 - 40.65 Mb
Chr 15:
82.05 - 82.05 Mb
PubMed search [1] [2]

Tumor necrosis factor receptor superfamily member 13C is a protein that in humans is encoded by the TNFRSF13C gene.[1][2]

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.[2]


  1. ^ Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C (Sep 2001). "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF". Science 293 (5537): 2108-11. doi:10.1126/science.1061965. PMID 11509692.  
  2. ^ a b "Entrez Gene: TNFRSF13C tumor necrosis factor receptor superfamily, member 13C".  

Further reading

  • Laâbi Y, Egle A, Strasser A (2002). "TNF cytokine family: more BAFF-ling complexities.". Curr. Biol. 11 (24): R1013–6. doi:10.1016/S0960-9822(01)00613-3. PMID 11747837.  
  • Defrance T, Casamayor-Pallejà M, Krammer PH (2003). "The life and death of a B cell.". Adv. Cancer Res. 86: 195–225. doi:10.1016/S0065-230X(02)86006-7. PMID 12374279.  
  • Ambrose CM (2003). "BAFF-R.". J. Biol. Regul. Homeost. Agents 16 (3): 211–3. PMID 12456020.  
  • Bossen C, Schneider P (2007). "BAFF, APRIL and their receptors: structure, function and signaling.". Semin. Immunol. 18 (5): 263–75. doi:10.1016/j.smim.2006.04.006. PMID 16914324.  
  • Treml LS, Crowley JE, Cancro MP (2007). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin. Immunol. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.  
  • Kalled SL (2007). "Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production.". Semin. Immunol. 18 (5): 290–6. doi:10.1016/j.smim.2006.06.002. PMID 16931038.  
  • Mackay F, Leung H (2007). "The role of the BAFF/APRIL system on T cell function.". Semin. Immunol. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039.  
  • Schneider P, MacKay F, Steiner V, et al. (1999). "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.". J. Exp. Med. 189 (11): 1747–56. doi:10.1084/jem.189.11.1747. PMID 10359578.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Yan M, Brady JR, Chan B, et al. (2002). "Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency.". Curr. Biol. 11 (19): 1547–52. doi:10.1016/S0960-9822(01)00481-X. PMID 11591325.  
  • Rolink AG, Melchers F (2002). "BAFFled B cells survive and thrive: roles of BAFF in B-cell development.". Curr. Opin. Immunol. 14 (2): 266–75. doi:10.1016/S0952-7915(02)00332-1. PMID 11869903.  
  • Xu LG, Shu HB (2003). "TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production.". J. Immunol. 169 (12): 6883–9. PMID 12471121.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kim HM, Yu KS, Lee ME, et al. (2003). "Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation.". Nat. Struct. Biol. 10 (5): 342–8. doi:10.1038/nsb925. PMID 12715002.  
  • Liu Y, Hong X, Kappler J, et al. (2003). "Ligand-receptor binding revealed by the TNF family member TALL-1.". Nature 423 (6935): 49–56. doi:10.1038/nature01543. PMID 12721620.  
  • Gordon NC, Pan B, Hymowitz SG, et al. (2003). "BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.". Biochemistry 42 (20): 5977–83. doi:10.1021/bi034017g. PMID 12755599.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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