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TNFRSF17: Wikis


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Tumor necrosis factor receptor superfamily, member 17

PDB rendering based on 1oqd.
Available structures
1oqd, 1xu2
Symbols TNFRSF17; BCM; BCMA; CD269
External IDs OMIM109545 MGI1343050 HomoloGene920 GeneCards: TNFRSF17 Gene
RNA expression pattern
PBB GE TNFRSF17 206641 at tn.png
More reference expression data
Species Human Mouse
Entrez 608 21935
Ensembl ENSG00000048462 ENSMUSG00000022496
UniProt Q02223 O88472
RefSeq (mRNA) NM_001192 NM_011608
RefSeq (protein) NP_001183 NP_035738
Location (UCSC) Chr 16:
11.97 - 11.97 Mb
Chr 16:
11.23 - 11.23 Mb
PubMed search [1] [2]

Tumor necrosis factor receptor superfamily member 17 is a protein that in humans is encoded by the TNFRSF17 gene.[1][2][3]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.[3]


TNFRSF17 has been shown to interact with B-cell activating factor.[4][5]


  1. ^ Laabi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ, Tsapis A (Nov 1992). "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma". EMBO J 11 (11): 3897–904. PMID 1396583.  
  2. ^ Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A (May 1994). "The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed". Nucleic Acids Res 22 (7): 1147–54. PMID 8165126.  
  3. ^ a b "Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17".  
  4. ^ Liu, Yingfang; Hong Xia, Kappler John, Jiang Ling, Zhang Rongguang, Xu Liangguo, Pan Cheol-Ho, Martin Wesley E, Murphy Robert C, Shu Hong-Bing, Dai Shaodong, Zhang Gongyi (May. 2003). "Ligand-receptor binding revealed by the TNF family member TALL-1". Nature (England) 423 (6935): 49–56. doi:10.1038/nature01543. ISSN 0028-0836. PMID 14749821.  
  5. ^ Shu, H B; Johnson H (Aug. 2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9156–61. doi:10.1073/pnas.160213497. ISSN 0027-8424. PMID 10908663.  

Further reading

  • Treml LS, Crowley JE, Cancro MP (2007). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin. Immunol. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.  
  • Mackay F, Leung H (2007). "The role of the BAFF/APRIL system on T cell function.". Semin. Immunol. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039.  
  • Gras MP, Laâbi Y, Linares-Cruz G, et al. (1996). "BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes.". Int. Immunol. 7 (7): 1093–106. doi:10.1093/intimm/7.7.1093. PMID 8527407.  
  • Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.  
  • Gross JA, Johnston J, Mudri S, et al. (2000). "TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.". Nature 404 (6781): 995–9. doi:10.1038/35010115. PMID 10801128.  
  • Hatzoglou A, Roussel J, Bourgeade MF, et al. (2000). "TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase.". J. Immunol. 165 (3): 1322–30. PMID 10903733.  
  • Shu HB, Johnson H (2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9156–61. doi:10.1073/pnas.160213497. PMID 10908663.  
  • Yu G, Boone T, Delaney J, et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.". Nat. Immunol. 1 (3): 252–6. doi:10.1038/79802. PMID 10973284.  
  • Kawasaki A, Tsuchiya N, Fukazawa T, et al. (2001). "Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis.". Genes Immun. 2 (5): 276–9. doi:10.1038/sj.gene.6363770. PMID 11528522.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Novak AJ, Darce JR, Arendt BK, et al. (2004). "Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival.". Blood 103 (2): 689–94. doi:10.1182/blood-2003-06-2043. PMID 14512299.  
  • Hymowitz SG, Patel DR, Wallweber HJ, et al. (2005). "Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.". J. Biol. Chem. 280 (8): 7218–27. doi:10.1074/jbc.M411714200. PMID 15542592.  
  • Bellucci R, Alyea EP, Chiaretti S, et al. (2005). "Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane receptor.". Blood 105 (10): 3945–50. doi:10.1182/blood-2004-11-4463. PMID 15692072.  
  • Hendriks J, Planelles L, de Jong-Odding J, et al. (2005). "Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation.". Cell Death Differ. 12 (6): 637–48. doi:10.1038/sj.cdd.4401647. PMID 15846369.  
  • Chiu A, Xu W, He B, et al. (2007). "Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL.". Blood 109 (2): 729–39. doi:10.1182/blood-2006-04-015958. PMID 16960154.  
  • Smirnova AS, Andrade-Oliveira V, Gerbase-Delima M (2008). "Identification of new splice variants of the genes BAFF and BCMA.". Molecular Immunology 45 (4): 1179–1183. doi:10.1016/j.molimm.2007.07.028. PMID 17825416.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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