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Tumor necrosis factor receptor superfamily, member 1A

PDB rendering based on 1ext.
Available structures
1ext, 1ft4, 1ich, 1ncf, 1tnr
Symbols TNFRSF1A; p55; TBP1; CD120a; FPF; MGC19588; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60; p55-R; p60
External IDs OMIM191190 MGI1314884 HomoloGene828 GeneCards: TNFRSF1A Gene
RNA expression pattern
PBB GE TNFRSF1A 207643 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7132 21937
Ensembl ENSG00000067182 ENSMUSG00000030341
UniProt P19438 Q3TVS9
RefSeq (mRNA) NM_001065 NM_011609
RefSeq (protein) NP_001056 NP_035739
Location (UCSC) Chr 12:
6.31 - 6.32 Mb
Chr 6:
125.32 - 125.33 Mb
PubMed search [1] [2]

Tumor necrosis factor receptor superfamily member 1A is a protein that in humans is encoded by the TNFRSF1A gene.[1][2] The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-kB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called periodic fever syndrome. Impaired receptor clearance is thought to be a mechanism of the disease.[3]



TNFRSF1A has been shown to interact with PSMD2,[4][5] FADD,[6][7] Tumor necrosis factor-alpha,[8][9] BAG4,[10][11] Janus kinase 2,[12] IKK2,[13][14] Caspase 10,[6][15] Janus kinase 1,[12][16] UBE2I,[17] TRPC4AP,[18] PIP4K2B,[19] TRAF2,[20][7][21] RIPK1,[22][23][20][24][25][26] TRADD[10][27][28][20][7][21][24] and Small ubiquitin-related modifier 1.[29][30]

See also


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  2. ^ Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GH, Gatanaga T, Granger GA, Lentz R, Raab H, et al. (Jun 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor". Cell 61 (2): 361–70. PMID 2158863.  
  3. ^ "Entrez Gene: TNFRSF1A tumor necrosis factor receptor superfamily, member 1A".  
  4. ^ Boldin, M P; Mett I L, Wallach D (Jun. 1995). "A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death domain'". FEBS Lett. (NETHERLANDS) 367 (1): 39–44. ISSN 0014-5793. PMID 7601280.  
  5. ^ Dunbar, J D; Song H Y, Guo D, Wu L W, Donner D B (May. 1997). "Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease". J. Immunol. (UNITED STATES) 158 (9): 4252–9. ISSN 0022-1767. PMID 9126987.  
  6. ^ a b Gajate, Consuelo; Mollinedo Faustino (Mar. 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. (United States) 280 (12): 11641–7. doi:10.1074/jbc.M411781200. ISSN 0021-9258. PMID 15659383.  
  7. ^ a b c Hsu, H; Shu H B, Pan M G, Goeddel D V (Jan. 1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell (UNITED STATES) 84 (2): 299–308. ISSN 0092-8674. PMID 8565075.  
  8. ^ Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14755267.  
  9. ^ Micheau, Olivier; Tschopp Jürg (Jul. 2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes". Cell (United States) 114 (2): 181–90. ISSN 0092-8674. PMID 12887914.  
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  11. ^ Miki, Kiyoshi; Eddy Edward M (Apr. 2002). "Tumor necrosis factor receptor 1 is an ATPase regulated by silencer of death domain". Mol. Cell. Biol. (United States) 22 (8): 2536–43. ISSN 0270-7306. PMID 11909948.  
  12. ^ a b Guo, D; Dunbar J D, Yang C H, Pfeffer L M, Donner D B (Mar. 1998). "Induction of Jak/STAT signaling by activation of the type 1 TNF receptor". J. Immunol. (UNITED STATES) 160 (6): 2742–50. ISSN 0022-1767. PMID 9510175.  
  13. ^ Zhang, S Q; Kovalenko A, Cantarella G, Wallach D (Mar. 2000). "Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation". Immunity (UNITED STATES) 12 (3): 301–11. ISSN 1074-7613. PMID 10755617.  
  14. ^ Chaudhary, P M; Eby M T, Jasmin A, Kumar A, Liu L, Hood L (Sep. 2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene (ENGLAND) 19 (39): 4451–60. doi:10.1038/sj.onc.1203812. ISSN 0950-9232. PMID 11002417.  
  15. ^ Vincenz, C; Dixit V M (Mar. 1997). "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling". J. Biol. Chem. (UNITED STATES) 272 (10): 6578–83. ISSN 0021-9258. PMID 9045686.  
  16. ^ Miscia, Sebastiano; Marchisio Marco, Grilli Alfredo, Di Valerio Valentina, Centurione Lucia, Sabatino Giuseppe, Garaci Francesco, Zauli Giorgio, Bonvini Ezio, Di Baldassarre Angela (Jan. 2002). "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth Differ. (United States) 13 (1): 13–8. ISSN 1044-9523. PMID 11801527.  
  17. ^ Saltzman, A; Searfoss G, Marcireau C, Stone M, Ressner R, Munro R, Franks C, D'Alonzo J, Tocque B, Jaye M, Ivashchenko Y (Apr. 1998). "hUBC9 associates with MEKK1 and type I TNF-alpha receptor and stimulates NFkappaB activity". FEBS Lett. (NETHERLANDS) 425 (3): 431–5. ISSN 0014-5793. PMID 9563508.  
  18. ^ Soond, Surinder M; Terry Jennifer L, Colbert Jeff D, Riches David W H (Nov. 2003). "TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB". Mol. Cell. Biol. (United States) 23 (22): 8334–44. ISSN 0270-7306. PMID 14585990.  
  19. ^ Castellino, A M; Parker G J, Boronenkov I V, Anderson R A, Chao M V (Feb. 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J. Biol. Chem. (UNITED STATES) 272 (9): 5861–70. ISSN 0021-9258. PMID 9038203.  
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  22. ^ Kim, J W; Choi E J, Joe C O (Sep. 2000). "Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP". Oncogene (ENGLAND) 19 (39): 4491–9. doi:10.1038/sj.onc.1203796. ISSN 0950-9232. PMID 11002422.  
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  27. ^ Schütze, S; Machleidt T, Adam D, Schwandner R, Wiegmann K, Kruse M L, Heinrich M, Wickel M, Krönke M (Apr. 1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. (UNITED STATES) 274 (15): 10203–12. ISSN 0021-9258. PMID 10187805.  
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Further reading

  • Rath PC, Aggarwal BB (2000). "TNF-induced signaling in apoptosis.". J. Clin. Immunol. 19 (6): 350–64. doi:10.1023/A:1020546615229. PMID 10634209.  
  • Chen G, Goeddel DV (2002). "TNF-R1 signaling: a beautiful pathway.". Science 296 (5573): 1634–5. doi:10.1126/science.1071924. PMID 12040173.  
  • Kollias G, Kontoyiannis D (2003). "Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments.". Cytokine Growth Factor Rev. 13 (4-5): 315–21. doi:10.1016/S1359-6101(02)00019-9. PMID 12220546.  
  • Dodé C, Cuisset L, Delpech M, Grateau G (2003). "TNFRSF1A-associated periodic syndrome (TRAPS), Muckle-Wells syndrome (MWS) and renal amyloidosis.". J. Nephrol. 16 (3): 435–7. PMID 12832748.  
  • Stojanov S, McDermott MF (2007). "The tumour necrosis factor receptor-associated periodic syndrome: current concepts.". Expert reviews in molecular medicine 7 (22): 1–18. doi:10.1017/S1462399405009749. PMID 16216134.  
  • Rezaei N (2007). "TNF-receptor-associated periodic syndrome (TRAPS): an autosomal dominant multisystem disorder.". Clin. Rheumatol. 25 (6): 773–7. doi:10.1007/s10067-005-0198-6. PMID 16447098.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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