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TNFRSF21: Wikis


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Tumor necrosis factor receptor superfamily, member 21

PDB rendering based on 2dbh.
Available structures
Symbols TNFRSF21; BM-018; DR6; MGC31965
External IDs OMIM605732 MGI2151075 HomoloGene8696 GeneCards: TNFRSF21 Gene
RNA expression pattern
PBB GE TNFRSF21 214581 x at tn.png
PBB GE TNFRSF21 218856 at tn.png
More reference expression data
Species Human Mouse
Entrez 27242 94185
Ensembl ENSG00000146072 ENSMUSG00000023915
UniProt O75509 Q3UPV2
RefSeq (mRNA) NM_014452 NM_178589
RefSeq (protein) NP_055267 NP_848704
Location (UCSC) Chr 6:
47.31 - 47.39 Mb
Chr 17:
42.48 - 42.55 Mb
PubMed search [1] [2]

Tumor necrosis factor receptor superfamily, member 21, also known as TNFRSF21, is a protein which in humans is encoded by the TNFRSF21 gene.[1][2]


The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-κB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T helper cell activation, and may be involved in inflammation and immune regulation.[2]


  1. ^ Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM (July 1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor". FEBS Lett. 431 (3): 351–6. PMID 9714541.  
  2. ^ a b "Entrez Gene: TNFRSF21 tumor necrosis factor receptor superfamily, member 21".  

Further reading

  • Pan G, Bauer JH, Haridas V, et al. (1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.". FEBS Lett. 431 (3): 351–6. doi:10.1016/S0014-5793(98)00791-1. PMID 9714541.  
  • Liu J, Na S, Glasebrook A, et al. (2001). "Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice.". Immunity 15 (1): 23–34. doi:10.1016/S1074-7613(01)00162-5. PMID 11485735.  
  • Zhao H, Yan M, Wang H, et al. (2001). "Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice.". J. Exp. Med. 194 (10): 1441–8. doi:10.1084/jem.194.10.1441. PMID 11714751.  
  • Kasof GM, Lu JJ, Liu D, et al. (2002). "Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB.". Oncogene 20 (55): 7965–75. doi:10.1038/sj.onc.1204985. PMID 11753679.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Mai T, Wang X, Zhang Z, et al. (2005). "Androgen receptor coregulator ARA267-alpha interacts with death receptor-6 revealed by the yeast two-hybrid.". Sci. China, C, Life Sci. 47 (5): 442–8. PMID 15623156.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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