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two pore segment channel 2
Symbols TPCN2; FLJ41094; TPC2; SHEP10
External IDs OMIM612163 MGI2385297 HomoloGene16375 IUPHAR: TPC2 GeneCards: TPCN2 Gene
Species Human Mouse
Entrez 219931 233979
Ensembl ENSG00000162341 ENSMUSG00000048677
UniProt n/a n/a
RefSeq (mRNA) NM_139075 NM_146206
RefSeq (protein) NP_620714 NP_666318
Location (UCSC) Chr 11:
68.57 - 68.61 Mb
Chr 7:
152.44 - 152.47 Mb
PubMed search [1] [2]

Two pore segment channel 2 (TPC2) is a human protein encoded by the TPCN2 is a protein which in humans is encoded by the TPCN2 gene.[1] TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).[2]


See also


  1. ^ "Entrez Gene: two pore segment channel 2".  
  2. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.  

Further reading

  • Sulem P, Gudbjartsson DF, Stacey SN, et al. (2008). "Two newly identified genetic determinants of pigmentation in Europeans.". Nat. Genet. 40 (7): 835-7. doi:10.1038/ng.160. PMID 18488028.  
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.  
  • Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.". Pharmacol. Rev. 57 (4): 451-4. doi:10.1124/pr.57.4.7. PMID 16382101.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Calcraft PJ, Ruas M, Pan Z, et al. (2009). "NAADP mobilizes calcium from acidic organelles through two-pore channels.". Nature 459 (7246): 596-600. doi:10.1038/nature08030. PMID 19387438.  
  • Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification.". Nature 440 (7083): 497-500. doi:10.1038/nature04632. PMID 16554811.  
  • Fu GK, Wang JT, Yang J, et al. (2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205-10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.  

External links



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