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TNF receptor-associated factor 2

PDB rendering based on 1ca4.
Available structures
1ca4, 1ca9, 1czy, 1czz, 1d00, 1d01, 1d0a, 1d0j, 1f3v, 1qsc
Symbols TRAF2; TRAP; MGC:45012; TRAP3
External IDs OMIM601895 MGI101835 HomoloGene22520 GeneCards: TRAF2 Gene
RNA expression pattern
PBB GE TRAF2 204413 at tn.png
More reference expression data
Species Human Mouse
Entrez 7186 22030
Ensembl ENSG00000127191 ENSMUSG00000026942
UniProt Q12933 Q3TWR1
RefSeq (mRNA) NM_021138 NM_009422
RefSeq (protein) NP_066961 NP_033448
Location (UCSC) Chr 9:
138.9 - 138.94 Mb
Chr 2:
25.34 - 25.37 Mb
PubMed search [1] [2]

TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.[1]

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms complexes with other TRAF proteins. TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. cIAP1 can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.[2]

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps


TRAF2 has been shown to interact with BCL10,[3] CD30,[4][5] CFLAR,[6][7] IKK2,[8][9] MAP3K7IP2,[10][9] CD137,[11][12] Caveolin 1,[13][14] CD27,[15][16] TNFRSF13B,[17] TANK-binding kinase 1,[18][19] TRAF1,[18][20] CD40,[21][22][23] UBE2N,[24] MAP3K14,[25][23] MAP4K2,[26] CASP8AP2,[27] HIVEP3,[28] TNFAIP3,[29] TNFRSF1B,[18][1][20][30][31][32][33] TNFRSF1A,[34][35][36] SPHK1,[37] Low affinity nerve growth factor receptor,[38] TNFRSF14,[39][32] CHUK,[40][8][9] CD134,[12] EDARADD,[41] RIPK1,[20][42][34][23] RANK,[43][44][45][46] TNFSF14,[47] TANK,[18][31][48][49] Baculoviral IAP repeat-containing protein 3,[50][51][3][52] BIRC2,[53][50][51][36][3][52] MAP4K5,[54] ASK1,[55][56][57] TRADD,[18][20][58][59][42][35][23] MAP3K1[60] and TRAF interacting protein.[61]


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Further reading

  • Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.". Cell. Signal. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.  
  • Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs).". Oncogene 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.  


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