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Transient receptor potential cation channel, subfamily C, member 1
Symbols TRPC1; TRP1; HTRP-1; MGC133334; MGC133335
External IDs OMIM602343 MGI109528 HomoloGene2478 IUPHAR: TRPC1 GeneCards: TRPC1 Gene
RNA expression pattern
PBB GE TRPC1 205803 s at tn.png
PBB GE TRPC1 205802 at tn.png
PBB GE TRPC1 211602 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7220 22063
Ensembl ENSG00000144935 ENSMUSG00000032839
UniProt P48995 Q61056
RefSeq (mRNA) NM_003304 NM_011643
RefSeq (protein) NP_003295 NP_035773
Location (UCSC) Chr 3:
143.93 - 144.01 Mb
Chr 9:
95.52 - 95.56 Mb
PubMed search [1] [2]

Transient receptor potential cation channel, subfamily C, member 1, also known as TRPC1, is a human gene encoding a protein of the same name.



TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1996 it was cloned when a research group headed by Lutz Birnbaumer was searching for proteins similar to the TRP channel in Drosophila. Together with TRPC3 it became the founding member of the TRPC ion channel family.[1]


TRPC1 has been shown to interact with HOMER3,[2] Polycystic kidney disease 2,[3] TRPC5,[4][5] TRPC3,[4][6] RHOA[7] and TRPC4.[4][5]

See also

Further reading

  • Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  • Rychkov G, Barritt GJ (2007). "TRPC1 Ca(2+)-permeable channels in animal cells.". Handb Exp Pharmacol 179 (179): 23–52. doi:10.1007/978-3-540-34891-7_2. PMID 17217049. 
  • Ambudkar IS (2007). "TRPC1: a core component of store-operated calcium channels.". Biochem. Soc. Trans. 35 (Pt 1): 96–100. doi:10.1042/BST0350096. PMID 17233611. 


  1. ^ Zhu X, Jiang M, Peyton M, et al. (May 1996). "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry". Cell 85 (5): 661–71. doi:10.1016/S0092-8674(00)81233-7. PMID 8646775. 
  2. ^ Yuan, Joseph P; Kiselyov Kirill, Shin Dong Ming, Chen Jin, Shcheynikov Nikolay, Kang Shin H, Dehoff Marlin H, Schwarz Martin K, Seeburg Peter H, Muallem Shmuel, Worley Paul F (Sep. 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell (United States) 114 (6): 777–89. ISSN 0092-8674. PMID 14505576. 
  3. ^ Tsiokas, L; Arnould T, Zhu C, Kim E, Walz G, Sukhatme V P (Mar. 1999). "Specific association of the gene product of PKD2 with the TRPC1 channel". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (7): 3934–9. ISSN 0027-8424. PMID 10097141. 
  4. ^ a b c Strübing, Carsten; Krapivinsky Grigory, Krapivinsky Luba, Clapham David E (Oct. 2003). "Formation of novel TRPC channels by complex subunit interactions in embryonic brain". J. Biol. Chem. (United States) 278 (40): 39014–9. doi:10.1074/jbc.M306705200. ISSN 0021-9258. PMID 12857742. 
  5. ^ a b Hofmann, Thomas; Schaefer Michael, Schultz Günter, Gudermann Thomas (May. 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (11): 7461–6. doi:10.1073/pnas.102596199. ISSN 0027-8424. PMID 12032305. 
  6. ^ Xu, X Z; Li H S, Guggino W B, Montell C (Jun. 1997). "Coassembly of TRP and TRPL produces a distinct store-operated conductance". Cell (UNITED STATES) 89 (7): 1155–64. ISSN 0092-8674. PMID 9215637. 
  7. ^ Mehta, Dolly; Ahmmed Gias U, Paria Biman C, Holinstat Michael, Voyno-Yasenetskaya Tatyana, Tiruppathi Chinnaswamy, Minshall Richard D, Malik Asrar B (Aug. 2003). "RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability". J. Biol. Chem. (United States) 278 (35): 33492–500. doi:10.1074/jbc.M302401200. ISSN 0021-9258. PMID 12766172. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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