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Transient receptor potential cation channel, subfamily C, member 4
Symbols TRPC4; HTRP4; MGC119570; MGC119571; MGC119572; MGC119573; TRP4
External IDs OMIM603651 MGI109525 HomoloGene22955 IUPHAR: TRPC4 GeneCards: TRPC4 Gene
RNA expression pattern
PBB GE TRPC4 220818 s at tn.png
PBB GE TRPC4 220817 at tn.png
More reference expression data
Species Human Mouse
Entrez 7223 22066
Ensembl ENSG00000133107 ENSMUSG00000027748
UniProt Q9UBN4 Q0VB97
RefSeq (mRNA) NM_016179 NM_016984
RefSeq (protein) NP_057263 NP_058680
Location (UCSC) Chr 13:
37.11 - 37.34 Mb
Chr 3:
54.24 - 54.41 Mb
PubMed search [1] [2]

Transient receptor potential cation channel, subfamily C, member 4, also known as TRPC4, is a human gene encoding a protein of the same name.



TRPC4 has been shown to interact with TRPC1,[1][2] ITPR1[3][4] and TRPC5.[2]

See also

Further reading

  • Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.  
  • Cavalié A (2007). "Ionic channels formed by TRPC4.". Handb Exp Pharmacol 179 (179): 93–108. doi:10.1007/978-3-540-34891-7_5. PMID 17217052.  


  1. ^ Strübing, Carsten; Krapivinsky Grigory, Krapivinsky Luba, Clapham David E (Oct. 2003). "Formation of novel TRPC channels by complex subunit interactions in embryonic brain". J. Biol. Chem. (United States) 278 (40): 39014–9. doi:10.1074/jbc.M306705200. ISSN 0021-9258. PMID 12857742.  
  2. ^ a b Hofmann, Thomas; Schaefer Michael, Schultz Günter, Gudermann Thomas (May. 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (11): 7461–6. doi:10.1073/pnas.102596199. ISSN 0027-8424. PMID 12032305.  
  3. ^ Yuan, Joseph P; Kiselyov Kirill, Shin Dong Ming, Chen Jin, Shcheynikov Nikolay, Kang Shin H, Dehoff Marlin H, Schwarz Martin K, Seeburg Peter H, Muallem Shmuel, Worley Paul F (Sep. 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell (United States) 114 (6): 777–89. ISSN 0092-8674. PMID 14505576.  
  4. ^ Mery, L; Magnino F, Schmidt K, Krause K H, Dufour J F (Jan. 2001). "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors". FEBS Lett. (Netherlands) 487 (3): 377–83. ISSN 0014-5793. PMID 11163362.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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