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Transient receptor potential cation channel, subfamily M, member 1
Symbols TRPM1; LTRPC1; MLSN1
External IDs OMIM603576 MGI1330305 HomoloGene19940 IUPHAR: TRPM1 GeneCards: TRPM1 Gene
RNA expression pattern
PBB GE TRPM1 206479 at tn.png
More reference expression data
Species Human Mouse
Entrez 4308 17364
Ensembl ENSG00000134160 ENSMUSG00000030523
UniProt Q7Z4N2 Q2TV84
RefSeq (mRNA) NM_002420 NM_001039104
RefSeq (protein) NP_002411 NP_001034193
Location (UCSC) Chr 15:
29.08 - 29.18 Mb
Chr 7:
64.03 - 64.15 Mb
PubMed search [1] [2]

Transient receptor potential cation channel subfamily M member 1 is a protein that in humans is encoded by the TRPM1 gene.[1][2][3]

The protein encoded by this gene is similar to the transient receptor potential (Trp) calcium channel family members. The expression of this protein is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis[4]. The expression of the TRPM1 gene is regulated by the Microphthalmia-associated transcription factor[5][6].


See also


  1. ^ Hunter JJ, Shao J, Smutko JS, Dussault BJ, Nagle DL, Woolf EA, Holmgren LM, Moore KJ, Shyjan AW (Jan 1999). "Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)". Genomics 54 (1): 116-23. doi:10.1006/geno.1998.5549. PMID 9806836.  
  2. ^ Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW (Apr 1998). "Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis". Cancer Res 58 (7): 1515-20. PMID 9537257.  
  3. ^ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev 57 (4): 427-50. doi:10.1124/pr.57.4.6. PMID 16382100.  
  4. ^ "Entrez Gene: TRPM1 transient receptor potential cation channel, subfamily M, member 1".  
  5. ^ Miller AJ, Du J, Rowan S, Hershey CL, Widlund HR, Fisher DE (2004). "Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma". Cancer Res. 64 (2): 509–16. doi:10.1158/0008-5472.CAN-03-2440. PMID 14744763.  
  6. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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