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Transient receptor potential cation channel, subfamily M, member 4
Symbols TRPM4; FLJ20041; TRPM4B
External IDs OMIM606936 MGI1915917 HomoloGene23033 IUPHAR: TRPM4 GeneCards: TRPM4 Gene
RNA expression pattern
PBB GE TRPM4 219360 s at tn.png
More reference expression data
Species Human Mouse
Entrez 54795 68667
Ensembl ENSG00000130529 ENSMUSG00000038260
UniProt Q8TD43 Q7TN37
RefSeq (mRNA) NM_017636 NM_175130
RefSeq (protein) NP_060106 NP_780339
Location (UCSC) Chr 19:
54.35 - 54.41 Mb
Chr 7:
45.17 - 45.2 Mb
PubMed search [1] [2]

Transient receptor potential cation channel, subfamily M, member 4, also known as TRPM4, is a human gene encoding a protein of the same name.

See also

Further reading

  • Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002). "TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.". Cell 109 (3): 397–407. doi:10.1016/S0092-8674(02)00719-5. PMID 12015988.  
  • Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP (2004). "TRPM4 regulates calcium oscillations after T cell activation.". Science 306 (5700): 1374–1377. doi:10.1126/science.1098845. PMID 15550671.  
  • Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.  
  • Vennekens R, Nilius B (2007). "Insights into TRPM4 function, regulation and physiological role.". Handb Exp Pharmacol 179 (179): 269–85. doi:10.1007/978-3-540-34891-7_16. PMID 17217063.  
  • Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M (2007). "Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4.". Nat Immunol 8 (3): 312–320. doi:10.1038/ni1441. PMID 17293867.  
  • Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P (2008). "The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells.". Nat Immunol 9 (10): 1148–56. doi:10.1038/ni.1648. PMID 18758465.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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