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TSC22 domain family, member 1
Symbols TSC22D1; DKFZp686O19206; MGC17597; RP11-269C23.2; TGFB1I4; TSC22
External IDs OMIM607715 MGI109127 HomoloGene7573 GeneCards: TSC22D1 Gene
RNA expression pattern
PBB GE TSC22D1 215111 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8848 21807
Ensembl ENSG00000102804 ENSMUSG00000022010
UniProt Q15714 Q3UXU0
RefSeq (mRNA) NM_006022 NM_009366
RefSeq (protein) NP_006013 NP_033392
Location (UCSC) Chr 13:
43.91 - 44.05 Mb
Chr 14:
75.15 - 75.24 Mb
PubMed search [1] [2]

TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.[1][2][1][2]

TSC22 encodes a transcription factor and belongs to the large family of early response genes.[3]

TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.[4]


  1. ^ a b Jay P, Ji JW, Marsollier C, Taviaux S, Berge-Lefranc JL, Berta P (Jul 1996). "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene". Biochem Biophys Res Commun 222 (3): 821-6. doi:10.1006/bbrc.1996.0825. PMID 8651929.  
  2. ^ a b Ohta S, Shimekake Y, Nagata K (Mar 1997). "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter". Eur J Biochem 242 (3): 460-6. PMID 9022669.  
  3. ^ "Entrez Gene: TSC22D1 TSC22 domain family, member 1".  
  4. ^ Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B (September 1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity". J. Biol. Chem. 274 (39): 27439–47. doi:10.1074/jbc.274.39.27439. PMID 10488076.  

Further reading

  • Shibanuma M, Kuroki T, Nose K (1992). "Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors.". J. Biol. Chem. 267 (15): 10219–24. PMID 1587811.  
  • Dmitrenko VV, Garifulin OM, Shostak EA, et al. (1997). "[The characteristics of different types of mRNA expressed in the human brain]". Tsitol. Genet. 30 (5): 41–7. PMID 9026990.  
  • Kester HA, Blanchetot C, den Hertog J, et al. (1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity.". J. Biol. Chem. 274 (39): 27439–47. doi:10.1074/jbc.274.39.27439. PMID 10488076.  
  • Hino S, Kawamata H, Uchida D, et al. (2001). "Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator.". Biochem. Biophys. Res. Commun. 278 (3): 659–64. doi:10.1006/bbrc.2000.3840. PMID 11095965.  
  • Hino S, Kawamata H, Omotehara F, et al. (2002). "Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells.". Oncol. Rep. 9 (2): 371–4. PMID 11836610.  
  • Hino S, Kawamata H, Omotehara F, et al. (2002). "Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells.". Biochem. Biophys. Res. Commun. 292 (4): 957–63. doi:10.1006/bbrc.2002.6776. PMID 11944908.  
  • Ohara O, Nagase T, Mitsui G, et al. (2003). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.". DNA Res. 9 (2): 47–57. doi:10.1093/dnares/9.2.47. PMID 12056414.  
  • Gupta RA, Sarraf P, Brockman JA, et al. (2003). "Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22.". J. Biol. Chem. 278 (9): 7431–8. doi:10.1074/jbc.M208076200. PMID 12468551.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Sugawara F, Yamada Y, Watanabe R, et al. (2004). "The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy.". Diabetes Res. Clin. Pract. 60 (3): 191–7. doi:10.1016/S0168-8227(03)00038-X. PMID 12757981.  
  • Uchida D, Omotehara F, Nakashiro K, et al. (2003). "Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1.". Biochem. Biophys. Res. Commun. 305 (4): 846–54. doi:10.1016/S0006-291X(03)00854-4. PMID 12767908.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Choi SJ, Moon JH, Ahn YW, et al. (2005). "Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation.". Mol. Cell. Biochem. 271 (1-2): 23–8. doi:10.1007/s11010-005-3456-7. PMID 15881652.  
  • Rentsch CA, Cecchini MG, Schwaninger R, et al. (2006). "Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer.". Int. J. Cancer 118 (4): 899–906. doi:10.1002/ijc.21449. PMID 16106424.  
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.  
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  
  • Lu Y, Kitaura J, Oki T, et al. (2007). "Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD.". Leukemia 21 (11): 2246–57. doi:10.1038/sj.leu.2404883. PMID 17690703.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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