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Twist homolog 2 (Drosophila)
Symbols TWIST2; DERMO1; MGC117334
External IDs OMIM607556 GeneCards: TWIST2 Gene
Species Human Mouse
Entrez 117581 n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) NM_057179 n/a
RefSeq (protein) NP_476527 n/a
Location (UCSC) n/a n/a
PubMed search [1] n/a

Twist-related protein 2 is a protein that in humans is encoded by the TWIST2 gene.[1][2][3]

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype.[3]



TWIST2 has been shown to interact with SREBF1.[4]


  1. ^ Li L, Cserjesi P, Olson EN (Dec 1995). "Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis". Dev Biol 172 (1): 280–92. doi:10.1006/dbio.1995.0023. PMID 7589808.  
  2. ^ Perrin-Schmitt F, Bolcato-Bellemin AL, Bourgeois P, Stoetzel C, Danse JM (Apr 1997). "The locations of the H-twist and H-dermo-1 genes are distinct on the human genome". Biochim Biophys Acta 1360 (1): 1–2. PMID 9061034.  
  3. ^ a b "Entrez Gene: TWIST2 twist homolog 2 (Drosophila)".  
  4. ^ Lee, Yun Sok; Lee Hyoung Ho, Park Jiyoung, Yoo Eung Jae, Glackin Carlotta A, Choi Young Il, Jeon Sung Ho, Seong Rho Hyun, Park Sang Dai, Kim Jae Bum (Dec. 2003). "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c". Nucleic Acids Res. (England) 31 (24): 7165–74. PMID 14654692.  

Further reading

  • Volorio S, Simon G, Repetto M, et al. (1999). "Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein.". DNA Seq. 9 (5-6): 307–15. doi:10.3109/10425179809008469. PMID 10524757.  
  • Lee MS, Lowe G, Flanagan S, et al. (2000). "Human Dermo-1 has attributes similar to twist in early bone development.". Bone 27 (5): 591–602. doi:10.1016/S8756-3282(00)00380-X. PMID 11062344.  
  • Gong XQ, Li L (2002). "Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation.". J. Biol. Chem. 277 (14): 12310–7. doi:10.1074/jbc.M110228200. PMID 11809751.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Lee YS, Lee HH, Park J, et al. (2004). "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c.". Nucleic Acids Res. 31 (24): 7165–74. doi:10.1093/nar/gkg934. PMID 14654692.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Firulli BA, Krawchuk D, Centonze VE, et al. (2005). "Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.". Nat. Genet. 37 (4): 373–81. doi:10.1038/ng1525. PMID 15735646.  
  • Raval A, Lucas DM, Matkovic JJ, et al. (2005). "TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia.". J. Clin. Oncol. 23 (17): 3877–85. doi:10.1200/JCO.2005.02.196. PMID 15809452.  
  • Terauchi M, Kajiyama H, Yamashita M, et al. (2007). "Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma.". Clin. Exp. Metastasis 24 (5): 329–39. doi:10.1007/s10585-007-9070-1. PMID 17487558.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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