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TYRO3 protein tyrosine kinase

PDB rendering based on 1rhf.
Available structures
1rhf
Identifiers
Symbols TYRO3; BYK; Brt; Dtk; RSE; Sky; Tif
External IDs OMIM600341 MGI104294 HomoloGene4585 GeneCards: TYRO3 Gene
RNA expression pattern
PBB GE TYRO3 211432 s at tn.png
PBB GE TYRO3 211431 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7301 22174
Ensembl ENSG00000092445 ENSMUSG00000027298
UniProt Q06418 Q6NZM6
RefSeq (mRNA) NM_006293 XM_001003157
RefSeq (protein) NP_006284 XP_001003157
Location (UCSC) Chr 15:
39.64 - 39.66 Mb
Chr 2:
119.49 - 119.51 Mb
PubMed search [1] [2]

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.[1][2]

Interactions

TYRO3 has been shown to interact with PIK3R1[3] and GAS6.[4][5]

References

  1. ^ Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C, et al. (Mar 1995). "Regional localization of human chromosome 15 loci". Genomics 23 (3): 619–27. PMID 7851890.  
  2. ^ "Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7301.  
  3. ^ Lan, Z; Wu H, Li W, Wu S, Lu L, Xu M, Dai W (Jan. 2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood (UNITED STATES) 95 (2): 633–8. ISSN 0006-4971. PMID 10627473.  
  4. ^ Mark, M R; Chen J, Hammonds R G, Sadick M, Godowsk P J (Apr. 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. (UNITED STATES) 271 (16): 9785–9. ISSN 0021-9258. PMID 8621659.  
  5. ^ Nagata, K; Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (Nov. 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. (UNITED STATES) 271 (47): 30022–7. ISSN 0021-9258. PMID 8939948.  

Further reading

  • Mark MR, Scadden DT, Wang Z, et al. (1994). "rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.". J. Biol. Chem. 269 (14): 10720–8. PMID 7511603.  
  • Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase.". Biochem. Biophys. Res. Commun. 209 (2): 656–63. doi:10.1006/bbrc.1995.1549. PMID 7537495.  
  • Crosier KE, Hall LR, Lewis PM, et al. (1995). "Isolation and characterization of the human DTK receptor tyrosine kinase.". Growth Factors 11 (2): 137–44. doi:10.3109/08977199409001055. PMID 7857658.  
  • Ohashi K, Mizuno K, Kuma K, et al. (1994). "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain.". Oncogene 9 (3): 699–705. PMID 8108112.  
  • Dai W, Pan H, Hassanain H, et al. (1994). "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis.". Oncogene 9 (3): 975–9. PMID 8108143.  
  • Polvi A, Armstrong E, Lai C, et al. (1994). "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25.". Gene 134 (2): 289–93. doi:10.1016/0378-1119(93)90109-G. PMID 8262388.  
  • Mark MR, Chen J, Hammonds RG, et al. (1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659.  
  • Crosier PS, Freeman SA, Orlic D, et al. (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis.". Exp. Hematol. 24 (2): 318–23. PMID 8641360.  
  • Nagata K, Ohashi K, Nakano T, et al. (1997). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948.  
  • Kajii Y, Ninomiya D, Kato M, et al. (1997). "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress.". Biol. Cell 88 (1-2): 45–54. doi:10.1016/S0248-4900(97)86830-X. PMID 9175267.  
  • Lan Z, Wu H, Li W, et al. (2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway.". Blood 95 (2): 633–8. PMID 10627473.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Yin JL, Hambly BD, Bao SS, et al. (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts.". Transpl. Int. 16 (9): 681–8. doi:10.1007/s00147-003-0593-3. PMID 12768229.  
  • Heiring C, Dahlbäck B, Muller YA (2004). "Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family.". J. Biol. Chem. 279 (8): 6952–8. doi:10.1074/jbc.M311750200. PMID 14623883.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Gould WR, Baxi SM, Schroeder R, et al. (2005). "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.". J. Thromb. Haemost. 3 (4): 733–41. doi:10.1111/j.1538-7836.2005.01186.x. PMID 15733062.  
  • Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases.". Int. J. Biochem. Cell Biol. 37 (11): 2344–56. doi:10.1016/j.biocel.2005.05.006. PMID 15964779.  
  • Shimojima M, Takada A, Ebihara H, et al. (2006). "Tyro3 family-mediated cell entry of Ebola and Marburg viruses.". J. Virol. 80 (20): 10109–16. doi:10.1128/JVI.01157-06. PMID 17005688.  
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