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Tachykinin receptor 3
Symbols TACR3; MGC148060; MGC148061; NK3R; TAC3RL
External IDs OMIM162332 MGI892968 HomoloGene824 IUPHAR: NK3 GeneCards: TACR3 Gene
RNA expression pattern
PBB GE TACR3 208183 at tn.png
More reference expression data
Species Human Mouse
Entrez 6870 21338
Ensembl ENSG00000169836 ENSMUSG00000028172
UniProt P29371 Q6NXX1
RefSeq (mRNA) NM_001059 NM_021382
RefSeq (protein) NP_001050 NP_067357
Location (UCSC) Chr 4:
104.73 - 104.86 Mb
Chr 3:
134.77 - 134.87 Mb
PubMed search [1] [2]

Tachykinin receptor 3, also known as TACR3, is a protein which in humans is encoded by the TACR3 gene.[1][2]



This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.[2]

Selective ligands

Several selective ligands are available for NK3, with two compounds osanetant and talnetant currently in clinical trials for treatment of schizophrenia and other indications.[3]



  • Senktide - 7-amino acid polypeptide, NK3 selective, CAS# 106128-89-6


  • Osanetant
  • Talnetant
  • SB-222,200 - potent and selective antagonist, Ki = 4.4 nM, 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide, CAS# 174635-69-9
  • SB-218,795 - more selective than SB-222,200, Ki = 13 nM, (R)-[(2-Phenyl-4-quinolinylcarbonyl)amino]-methyl ester benzeneacetic acid, CAS# 174635-53-1

See also


  1. ^ Huang RR, Cheung AH, Mazina KE, Strader CD, Fong TM (April 1992). "cDNA sequence and heterologous expression of the human neurokinin-3 receptor". Biochem. Biophys. Res. Commun. 184 (2): 966–72. doi:10.1016/0006-291X(92)90685-E. PMID 1374246.  
  2. ^ a b "Entrez Gene: TACR3 tachykinin receptor 3".  
  3. ^ Quartara L, Altamura M (August 2006). "Tachykinin receptors antagonists: from research to clinic". Curr Drug Targets 7 (8): 975–92. doi:10.2174/138945006778019381. PMID 16918326.  

Further reading

  • Khawaja AM, Rogers DF (1996). "Tachykinins: receptor to effector.". Int. J. Biochem. Cell Biol. 28 (7): 721–38. doi:10.1016/1357-2725(96)00017-9. PMID 8925404.  
  • Advenier C, Lagente V, Boichot E (1997). "The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough.". Eur. Respir. J. 10 (8): 1892–906. doi:10.1183/09031936.97.10081892. PMID 9272936.  
  • Buell G, Schulz MF, Arkinstall SJ, et al. (1992). "Molecular characterisation, expression and localisation of human neurokinin-3 receptor.". FEBS Lett. 299 (1): 90–5. doi:10.1016/0014-5793(92)80107-R. PMID 1312036.  
  • Takahashi K, Tanaka A, Hara M, Nakanishi S (1992). "The primary structure and gene organization of human substance P and neuromedin K receptors.". Eur. J. Biochem. 204 (3): 1025–33. doi:10.1111/j.1432-1033.1992.tb16724.x. PMID 1312928.  
  • Xie GX, Miyajima A, Goldstein A (1992). "Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands.". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 4124–8. doi:10.1073/pnas.89.9.4124. PMID 1315051.  
  • Huang RR, Cheung AH, Mazina KE, et al. (1992). "cDNA sequence and heterologous expression of the human neurokinin-3 receptor.". Biochem. Biophys. Res. Commun. 184 (2): 966–72. doi:10.1016/0006-291X(92)90685-E. PMID 1374246.  
  • Dion S, Corcos J, Carmel M, et al. (1988). "Substance P and neurokinins as stimulants of the human isolated urinary bladder.". Neuropeptides 11 (2): 83–7. doi:10.1016/0143-4179(88)90015-7. PMID 2452993.  
  • Krause JE, Staveteig PT, Mentzer JN, et al. (1997). "Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.". Proc. Natl. Acad. Sci. U.S.A. 94 (1): 310–5. doi:10.1073/pnas.94.1.310. PMID 8990205.  
  • Brunelleschi S, Bordin G, Colangelo D, Viano I (1999). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis.". Neuropeptides 32 (3): 215–23. doi:10.1016/S0143-4179(98)90040-3. PMID 10189055.  
  • Page NM, Woods RJ, Gardiner SM, et al. (2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia.". Nature 405 (6788): 797–800. doi:10.1038/35015579. PMID 10866201.  
  • Bellucci F, Carini F, Catalani C, et al. (2002). "Pharmacological profile of the novel mammalian tachykinin, hemokinin 1.". Br. J. Pharmacol. 135 (1): 266–74. doi:10.1038/sj.bjp.0704443. PMID 11786503.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Graham GJ, Stevens JM, Page NM, et al. (2005). "Tachykinins regulate the function of platelets.". Blood 104 (4): 1058–65. doi:10.1182/blood-2003-11-3979. PMID 15130944.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Page NM, Dakour J, Morrish DW (2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia.". Mol. Hum. Reprod. 12 (7): 427–33. doi:10.1093/molehr/gal025. PMID 16709596.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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