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Tandamine: Wikis


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Systematic (IUPAC) name
CAS number 42408-80-0
ATC code none
PubChem 39187
Chemical data
Formula C 18H26N2S 
Mol. mass 302.476 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Tandamine is a heterocyclic antidepressant. It acts as a selective norepinephrine reuptake inhibitor and also has weak anticholinergic effects that are much less prominent than those seen with the tricyclic antidepressants (TCAs).[1][2][3]


  1. ^ Lippmann W, Pugsley TA (May 1976). "The effects of tandamine, a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities". Biochemical Pharmacology 25 (10): 1179–86. PMID 1084746.  
  2. ^ Ehsanullah RS, Ghose K, Kirby MJ, Turner P, Witts D (March 1977). "Clinical pharmacological studies of tandamine, a potential antidepressive drug". Psychopharmacology 52 (1): 73–7. PMID 403562.  
  3. ^ Pugsley TA, Lippmann W (September 1979). "Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities". Naunyn-Schmiedeberg's Archives of Pharmacology 308 (3): 239–47. PMID 503251.  


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