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Teplizumab: Wikis

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From Wikipedia, the free encyclopedia

Teplizumab ?
Monoclonal antibody
Source humanized murine antibody
Target CD3
Identifiers
CAS number 876387-05-2
ATC code none
Chemical data
Formula C6462H9938N1738O2022S46 
Mol. mass 145.8 kDa
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Teplizumab is a monoclonal antibody which is used as an immunosuppressive drug. It has been used experimentally in type 1 diabetes mellitus[1], but "these agents [i. e. anti-CD3-antibodies] alone do not restore normal glucose control".[2]

Teplizumab is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala).[3][4]

References

  1. ^ Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA (June 2005). "A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes". Diabetes 54 (6): 1763–9. PMID 15919798. http://diabetes.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=15919798. 
  2. ^ Kaufman A, Herold KC (May 2009). "Anti-CD3 mAbs for treatment of type 1 diabetes". Diabetes/metabolism Research and Reviews 25 (4): 302–6. doi:10.1002/dmrr.933. PMID 19319985. http://dx.doi.org/10.1002/dmrr.933. 
  3. ^ Woodle ES, Bluestone JA, Zivin RA, Jolliffe LK, Auger J, Xu D, Thistlethwaite JR (June 1998). "Humanized, nonmitogenic OKT3 antibody, huOKT3 gamma(Ala-Ala): initial clinical experience". Transplant. Proc. 30 (4): 1369–70. PMID 9636555. http://linkinghub.elsevier.com/retrieve/pii/S0041134598002784. 
  4. ^ Brown WM (April 2006). "Anti-CD3 antibody MacroGenics Inc". Curr Opin Investig Drugs 7 (4): 381–8. PMID 16625825. 

External links

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