The Full Wiki

More info on Teplizumab

Teplizumab: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Teplizumab ?
Monoclonal antibody
Source humanized murine antibody
Target CD3
CAS number 876387-05-2
ATC code none
Chemical data
Formula C6462H9938N1738O2022S46 
Mol. mass 145.8 kDa
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Teplizumab is a monoclonal antibody which is used as an immunosuppressive drug. It has been used experimentally in type 1 diabetes mellitus[1], but "these agents [i. e. anti-CD3-antibodies] alone do not restore normal glucose control".[2]

Teplizumab is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala).[3][4]


  1. ^ Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA (June 2005). "A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes". Diabetes 54 (6): 1763–9. PMID 15919798. 
  2. ^ Kaufman A, Herold KC (May 2009). "Anti-CD3 mAbs for treatment of type 1 diabetes". Diabetes/metabolism Research and Reviews 25 (4): 302–6. doi:10.1002/dmrr.933. PMID 19319985. 
  3. ^ Woodle ES, Bluestone JA, Zivin RA, Jolliffe LK, Auger J, Xu D, Thistlethwaite JR (June 1998). "Humanized, nonmitogenic OKT3 antibody, huOKT3 gamma(Ala-Ala): initial clinical experience". Transplant. Proc. 30 (4): 1369–70. PMID 9636555. 
  4. ^ Brown WM (April 2006). "Anti-CD3 antibody MacroGenics Inc". Curr Opin Investig Drugs 7 (4): 381–8. PMID 16625825. 

External links



Got something to say? Make a comment.
Your name
Your email address