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Terazosin
Systematic (IUPAC) name
6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
Identifiers
CAS number 63590-64-7
ATC code G04CA03
PubChem 5401
DrugBank APRD00667
Chemical data
Formula C19H25N5O4 
Mol. mass 387.433 g/mol
Synonyms [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone
Pharmacokinetic data
Protein binding 90-94%
Half life 12 hours
Therapeutic considerations
Pregnancy cat.  ?
Legal status
 Yes check.svgY(what is this?)  (verify)

Terazosin (marketed as Hytrin) is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It also acts to lower the blood pressure, and is therefore a drug of choice for men with hypertension and prostate enlargement.

It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

Most common side effects include dizziness, drowsiness, headache, constipation, loss of appetite, fatigue, nasal congestion or dry eyes, but they generally go away after only a few days of use. Therapy should always be started with a low dose to avoid first dose phenomenon.[1] Sexual side effects are rare, but may include priapism or erectile dysfunction.

References

  1. ^ Hytrin (Terazosin Hcl) drug warnings and precautions - prescription drugs and medications at RxList







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