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Terbutaline: Wikis

  

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Terbutaline
Systematic (IUPAC) name
(RS)-5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol
Identifiers
CAS number 23031-25-6
ATC code R03AC03 R03CC03
PubChem 5403
DrugBank APRD00589
ChemSpider 5210
Chemical data
Formula C 12H19NO3  
Mol. mass 225.284 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism GI tract (oral), liver; CYP450: unknown
Half life 3-4h
Excretion urine 90% (60% unchanged), bile/faeces
Therapeutic considerations
Pregnancy cat. B
Legal status POM (UK)
Routes SQ, Oral, Inhaled
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Terbutaline (trade names Brethine, Bricanyl, or Brethaire) is a β2-adrenergic receptor agonist, used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic to delay premature labour. The inhaled form of terbutaline starts working within 15 minutes and can last up to 6 hours.

Terbutaline as a treatment for premature labour is an off-label use not approved by the FDA. It is a pregnancy category 'B' medication and is routinely prescribed to stop contractions. Terbutaline is currently on the World Anti-Doping Agency's list of prohibited drugs for Olympic athletes, except when administered by inhalation and a Therapeutic Use Exemption (TUE) has been obtained in advance.Orally disintegrating tablets by sublimation technique of Terbutaline sulphate have been developed.[1]

Side effects

References

  1. ^ 1. Ashok Kumar, Anuj G. Agrawal. (2009) "Formulation, development and evaluation of orally disintegrating tablets by sublimation technique.". International Journal of PharmTech Research (4), 997-999. http://sphinxsai.com/PTVOL4/pdf_vol4/PT=5%20%20(997-99).pdf
  2. ^ Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. pp. 7. ISBN 1-59541-101-1.  







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