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Terlipressin
Systematic (IUPAC) name
1-{[(4R,7S,10S,13 S,16S,19R)-19-{[({[(aminoacetyl)amino]acetyl}amino)acetyl]amino}-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}- L-prolyl-N-(2-amino-2-oxoethyl)-L-lysinamide
Identifiers
CAS number 14636-12-5
ATC code H01BA04
PubChem 72081
DrugBank EXPT03310
Chemical data
Formula C 52H74N16O15S2  
Mol. mass 1227.37 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding ~30%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes IV

Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.

Indications for use include norepinephrine-resistant septic shock[1] and hepatorenal syndrome.[2] In addition, it is used in bleeding esophageal varices.[3]

Terlipressin is marketed under the brand names Haemopressin (IS Pharmaceuticals), Variquel (IS Pharmaceuticals) or Glypressin (Ferring Pharmaceuticals).

Availability

Terlipressin is currently not available in the United States,[4] or Canada.[5]

See also

References

  1. ^ O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet 359 (9313): 1209–10. doi:10.1016/S0140-6736(02)08225-9. PMID 11955542.  
  2. ^ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol 33 (1): 43–8. doi:10.1016/S0168-8278(00)80158-0. PMID 10905585.  
  3. ^ Ioannou G, Doust J, Rockey D (2003). "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev: CD002147. doi:10.1002/14651858.CD002147. PMID 12535432.  
  4. ^ "{1} And {2} Report Fast Track Designation For Terlipressin In Type 1 Hepatorenal Syndrome - News, Search Jobs, Events". http://www.biospace.com/news_story.aspx?NewsEntityId=19774820.  
  5. ^ "Drug Product Search". http://205.193.93.51/dpdonline/searchRequest.do.  







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