The Full Wiki

More info on Testicular receptor 2

Testicular receptor 2: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Nuclear receptor subfamily 2, group C, member 1
Identifiers
Symbols NR2C1; TR2; TR2-11
External IDs OMIM601529 MGI1352465 HomoloGene55731 GeneCards: NR2C1 Gene
RNA expression pattern
PBB GE NR2C1 210530 s at tn.png
PBB GE NR2C1 210531 at tn.png
PBB GE NR2C1 204791 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7181 22025
Ensembl ENSG00000120798 ENSMUSG00000005897
UniProt P13056 Q0VGP8
RefSeq (mRNA) NM_001032287 NM_011629
RefSeq (protein) NP_001027458 NP_035759
Location (UCSC) Chr 12:
93.94 - 93.99 Mb
Chr 10:
93.58 - 93.63 Mb
PubMed search [1] [2]

The testicular receptor 2 (TR2) is a member of the nuclear receptor family of transcription factors. TR2 is encoded by the NR2C1 gene (nuclear receptor subfamily 2, group C, member 1).[1]

Contents

Interactions

Testicular receptor 2 has been shown to interact with Estrogen receptor alpha,[2] HDAC3,[3][4][5] HDAC4[4][5] and Androgen receptor.[6]

See also

References

  1. ^ "Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7181.  
  2. ^ Hu, Yueh-Chiang; Shyr Chih-Rong, Che Wenyi, Mu Xiao-Min, Kim Eungseok, Chang Chawnshang (Sep. 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". J. Biol. Chem. (United States) 277 (37): 33571–9. doi:10.1074/jbc.M203531200. ISSN 0021-9258. PMID 12093804.  
  3. ^ Li, Guangjin; Franco Peter J, Wei Li-Na (Oct. 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochem. Biophys. Res. Commun. (United States) 310 (2): 384–90. ISSN 0006-291X. PMID 14521922.  
  4. ^ a b Franco, Peter J; Li Guangjin, Wei Li-Na (Aug. 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Mol. Cell. Endocrinol. (Ireland) 206 (1-2): 1–12. ISSN 0303-7207. PMID 12943985.  
  5. ^ a b Franco, P J; Farooqui M, Seto E, Wei L N (Aug. 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Mol. Endocrinol. (United States) 15 (8): 1318–28. ISSN 0888-8809. PMID 11463856.  
  6. ^ Mu, Xiaomin; Chang Chawnshang (Oct. 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". Prostate (United States) 57 (2): 129–33. doi:10.1002/pros.10282. ISSN 0270-4137. PMID 12949936.  

Further reading

  • Chang C, Kokontis J, Acakpo-Satchivi L, et al. (1990). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains.". Biochem. Biophys. Res. Commun. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.  
  • Chang C, Kokontis J (1988). "Identification of a new member of the steroid receptor super-family by cloning and sequence analysis.". Biochem. Biophys. Res. Commun. 155 (2): 971–7. doi:10.1016/S0006-291X(88)80591-6. PMID 3421977.  
  • Lin DL, Wu SQ, Chang C (1998). "The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily.". Endocrine 8 (2): 123–34. doi:10.1385/ENDO:8:2:123. PMID 9704569.  
  • Lee CH, Chinpaisal C, Wei LN (1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4.". J. Biol. Chem. 273 (39): 25209–15. doi:10.1074/jbc.273.39.25209. PMID 9737983.  
  • Lee CH, Chinpaisal C, Wei LN (1998). "Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2.". Mol. Cell. Biol. 18 (11): 6745–55. PMID 9774688.  
  • Yu Z, Lee CH, Chinpaisal C, Wei LN (1999). "A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2.". J. Endocrinol. 159 (1): 53–60. doi:10.1677/joe.0.1590053. PMID 9795341.  
  • Franco PJ, Farooqui M, Seto E, Wei LN (2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases.". Mol. Endocrinol. 15 (8): 1318–28. doi:10.1210/me.15.8.1318. PMID 11463856.  
  • Tanabe O, Katsuoka F, Campbell AD, et al. (2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer.". EMBO J. 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMID 12093744.  
  • Hu YC, Shyr CR, Che W, et al. (2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor.". J. Biol. Chem. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Inui S, Lee YF, Chang E, et al. (2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.". J. Dermatol. Sci. 31 (1): 65–71. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366.  
  • Franco PJ, Li G, Wei LN (2004). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase.". Mol. Cell. Endocrinol. 206 (1-2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985.  
  • Mu X, Chang C (2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3.". Prostate 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936.  
  • Li G, Franco PJ, Wei LN (2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2.". Biochem. Biophys. Res. Commun. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.  
  • Lin YL, Wang YH, Lee HJ (2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A.". Biochem. Biophys. Res. Commun. 350 (2): 430–6. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message