Testosterone poisoning is a pejorative neologism that refers not to actual poisoning, but to a negative perception of stereotypical aspects of male behavior. This speculative and controversial expression is based on a belief that men and boys with more masculine traits have more negative traits than they would otherwise. Masculinity, as represented by the androgen testosterone, is associated with "poisoning" or a negative outcome.
James Dabbs states that
"identifying testosterone with aggression is an idea whose time has come and gone."
"Everyone knows that testosterone, the so-called male hormone, is found in both men and women. What is not so well known, is that men have an overdose... Until now it has been thought that the level of testosterone in men is normal simply because they have it. But if you consider how abnormal their behavior is, then you are led to the hypothesis that almost all men are suffering from testosterone poisoning."
Ten years later, that same sentence from Alda's article was quoted in the 1985 book A Feminist Dictionary2.
A book of searing analysis and cries from the heart on the madness of war. Why is the half of humanity with a special sensitivity to the preciousness of life, the half untainted by testosterone poisoning, almost wholly unrepresented in defense establishments and peace negotiations worldwide?3
Bruce Tremper used the term in The Avalanche Review, stating that being "a man" is best proven by dying "a stupendously violent death."5
Testosterone poisoning is not an actual medical or psychological condition. A 1996 Psychology Today article refers to the phrase as "only a joke," but notes, in reference to several studies about testosterone and male employment, that testosterone levels were lower for successful new male employees at a southern U.S. oil firm.6
In the words of James Dabbs, a researcher in this area,
"Identifying testosterone with aggression is an idea whose time has come and gone" (Dabbs, 1998) .
Mazur et al. (1998) stated that males with higher testosterone levels tend to be slightly more aggressive, and argue that this appears to be due to the way acting aggressively raises testosterone levels rather than the reverse.
However Anderson RA et al. stated that increasing level of testosterone in men does not increase self-reported ratings of aggressive feelings .O'Connor R. et al. founds that injections of testosterone has limited psychological effect and does not lead to aggressive behaviour or mood. 
References to testosterone poisoning are often used to criticize men. Magazine editor Tina Brown uses the phrase thematically in a 2005 Washington Post essay about the downfall of Harvard University president Larry Summers and the problems of Disney's former embattled CEO Michael Eisner.8 Beth Gallagher's Salon.com essay "Road Sows" about the drawbacks of sports utility vehicles describes those vehicles' growing popularity as having spread beyond testosterone poisoned men to soccer moms.9 Dr. Karl Albrecht makes testosterone poisoning a synonym for male chauvinism in his 2002 book The Power of Minds at Work: Organizational Intelligence in Action where he describes it as one of 17 basic syndromes of dysfunction.10
Occasionally this perceived moral decadence of men turns against women, as in Kay S. Hymowitz's sarcastic reference to Western feminists in a 2003 Wall Street Journal essay chiding them for neglecting the rights of Third World women in Muslim countries:
Antonia Feitz has protested against the use of the expression in a 1999 essay in the Australian Daily Issues Paper, calling it hate speech.15 Neuroscientist Christoph Eisenegger at the University of Zurich has conducted a study and concludes that the evidence debunks the myth that testosterone causes aggressive, egocentric behaviour, suggesting instead that the sex hormone can encourage fair play, particularly if it improves a person's status. <http://timesofindia.indiatimes.com/life/spirituality/self-help/Testosterone-leads-to-fairness-not-aggression/articleshow/5318244.cms>