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Tetrahydrobiopterin: Wikis

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Tetrahydrobiopterin
Systematic (IUPAC) name
(6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1H)-pteridinone
Identifiers
CAS number 17528-72-2
ATC code A16AX07
PubChem 44257
ChemSpider 1093
Chemical data
Formula C9H15N5O3 
Mol. mass 241.25
Therapeutic considerations
Licence data

US FDA:link

Pregnancy cat. C(US)
Legal status -only (US)
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Tetrahydrobiopterin (THB, BH4; Kuvan) or sapropterin, is a naturally occurring nutrient and essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine (5-HT)), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and nitric oxide (NO).

Contents

History

THB was discovered to play a role as an enzymatic cofactor by Seymour Kaufman. The first enzyme found to use THB is phenylalanine hydroxylase (PAH).[1]

Biosynthesis

THB is biosynthesized from guanosine triphosphate (GTP) by three chemical reactions, those of which are mediated by the enzymes (GTP cyclohydrolase I (GTPCH), 6-pyruvoyltetrahydropterin synthase (PTPS), and sepiapterin reductase (SPR).[2]

Functions

THB has the following responsibilities as a cofactor:

Significance

A deficit in THB biosynthesis and/or regeneration results in phenylketonuria (PKU) from excess L-phenylalanine concentrations or hyperphenylalaninemia (HPA), as well as monoamine and nitric oxide neurotransmitter deficiency or chemical imbalance. The chronic presence of PKU can result in severe brain damage, including symptoms of mental retardation, microcephaly, speech impediments such as stuttering, slurring, and lisps, seizures or convulsions, and behavioral abnormalities, among other effects.

THB, developed by BioMarin under the brand name Kuvan and approved by the United States (U.S.) Food and Drug Administration (FDA) on December 13, 2007, is a synthetic preparation of the dihydrochloride salt of the substance, used in the treatment of PKU.[3] HPA due to THB deficiency-mediated PKU. Sapropterin is the first non-dietary treatment for patients with PKU that has been shown in randomized, double-blind trials to be effective in lowering blood phenylalanine levels. [4]

According to researchers at the University of Illinois at Chicago, THB may be of benefit in the management and treatment of intractable systolic heart failure based on research in mice. This is especially significant given that THB has already been tested and determined to be safe in human patients using it in the management of phenylketonuria, and also because there are far fewer ways to manage systolic heart failure than for diastolic heart failure.

See also

References

  1. ^ Kaufman, S (1 February 1958). "A New Cofactor Required for the Enzymatic Conversion of Phenylalanine to Tyrosine.". J. Biol. Chem. 230 (230): 931–939. http://www.jbc.org/cgi/reprint/230/2/931. 
  2. ^ Thony B, Auerbach G, Blau N (2000). "Tetrahydrobiopterin Biosynthesis, Regeneration and Functions.". Biochem J 347 Pt. 1: 1–16. doi:10.1042/0264-6021:3470001. PMID 10727395. http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=10727395. 
  3. ^ Barbara K. Burton, Santwana Kar & Peter Kirkpatrick (2008). "Fresh from the Pipeline: Sapropterin.". Nature Reviews Drug Discovery 7: 199–200. doi:10.1038/nrd2540. 
  4. ^ Sanford M, Keating GM.[1].Drugs 2009; 69(4):461-476.doi: 10.2165/00003495-200969040-00006.

External links

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