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Tetrazolylglycine: Wikis

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Tetrazolylglycine
Tetrazolylglycine.svg
IUPAC name
Identifiers
CAS number 138199-51-6
PubChem 126383
SMILES
Properties
Molecular formula C3H5N5O2
Molar mass 143.104
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Tetrazolylglycine (Tet-Gly, LY-285,265) is a potent and selective NMDA receptor agonist, stimulating the NMDA receptor with higher potency than either glutamate or NMDA.[1] It is a potent convulsant and excitotoxin and is used in scientific research.[2][3]

References

  1. ^ Lunn WH, Schoepp DD, Calligaro DO, Vasileff RT, Heinz LJ, Salhoff CR, O'Malley PJ. DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy. Journal of Medicinal Chemistry. 1992 Nov 27;35(24):4608-12. PMID 1361579
  2. ^ Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. European Journal of Pharmacology. 1991 Oct 15;203(2):237-43. PMID 1686860
  3. ^ Schoepp DD, Lunn WH, Salhoff CR, McDonald JW. The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin. European Journal of Pharmacology. 1994 Jan 3;270(1):67-72. PMID 8157082
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