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Thermogenesis: Wikis


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From Wikipedia, the free encyclopedia

Thermogenesis is the process of heat production in organisms. It occurs mostly in warm-blooded animals, but a few species of thermogenic plants exist.



Depending on whether they are initiated through locomotion and intentional movement of the muscles, thermogenic methods can be classified as one of the following:

  • Exercise-associated thermogenesis (EAT)
  • Non-exercise-associated thermogenesis (NEAT)
  • Diet- induced thermogenesis (DIT)


One method to raise temperature is through shivering. The heat results from friction between muscle elements (the same as during exertion), but no mechanical work is produced because opposing (antagonistic) muscle pairs are activated at the same time.

Non-shivering thermogenesis

Activation cascade of thermogenin in cells of brown adipose tissue

Non-shivering thermogenesis usually occurs in brown adipose tissue (brown fat) that is present in human infants, and hibernating mammals. It is a process whereby substances such as free fatty acids (derived from triacylglycerols) remove purine (ADP, GDP and others) inhibition of thermogenin (uncoupling protein-1), which causes an influx of H+ into the matrix of the mitochondria and bypasses the ATP synthase channel. This uncouples oxidative phosphorylation, and the energy from the proton motive force is dissipated as heat rather than producing ATP from ADP.

The low demands of thermogenesis mean that free fatty acids draw, for the most part, on lipolysis as the method of energy production.

Artificial thermogenesis

Thermogenesis can also be achieved by artificial means. It is becoming common for people to use thermogenic substances to help control fluctuation in weight. The process works by increasing the body's metabolism, thereby increasing its core temperature. Thermogenics are commonly made up of ephedra, bitter orange, capsicum, ginger, and caffeine.

Although bodybuilding formulations comprise the most common use of thermogenics, the drugs are entering the mainstream dieting industry.

See also

External links


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