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Thiamylal: Wikis


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Systematic (IUPAC) name
5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1 H,5H)-dione
CAS number 77-27-0
ATCvet code QN01AF90
PubChem 3032285
Chemical data
Formula C 12H18N2O2S 
Mol. mass 254.35 g/mol
Synonyms Thiamylal, Thioseconal, Surital
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule III (CA) Schedule III (US)
Routes  ?
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Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, and is used as a strong but short acting sedative. Thamylal is still in current use, primarily for induction in surgical anaesthesia [1] or as an anticonvulsant to counteract side effects from other anaesthetics. [2] It is the Thiobarbiturate anologue of secobarbital.


  1. ^ Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300.
  2. ^ Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100.


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